Degradation of FA reduces Aβ neurotoxicity and Alzheimer-related phenotypes
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-00929-7
Abstract: Dysregulation of formaldehyde (FA) has been implicated in the development of Alzheimer’s Disease (AD). Elevated FA levels in Alzheimer’s patients and animal models are associated with impaired cognitive functions. However, the exact role of FA… read more here.
Keywords: degradation; aggregation; degradation reduces; alzheimer related ... See more keywords
Alzheimer-Related Protein Suppresses Gliomas.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nb2020-005
Abstract: In low-grade gliomas, mutant forms of IDH1/2 trigger expression of tau, a protein typically associated with neurodegenerative disease that also inhibits EGFR signaling to impede tumor progression. The new findings provide a scientific rationale for… read more here.
Keywords: protein; protein suppresses; alzheimer related; suppresses gliomas ... See more keywords
Oxidative Damages on the Alzheimer’s Related-Aβ Peptide Alters Its Ability to Assemble
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12020472
Abstract: Oxidative stress that can lead to oxidation of the amyloid-β (Aβ) peptide is considered a key feature in Alzheimer’s disease (AD), influencing the ability of Aβ to assemble into β-sheet rich fibrils that are commonly… read more here.
Keywords: ability assemble; peptide; damages alzheimer; oxidative damages ... See more keywords
Why the Ala-His-His Peptide Is an Appropriate Scaffold to Remove and Redox Silence Copper Ions from the Alzheimer’s-Related Aβ Peptide
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12101327
Abstract: The progressive, neurodegenerative Alzheimer’s disease (AD) is the most widespread dementia. Due to the ageing of the population and the current lack of molecules able to prevent or stop the disease, AD will be even… read more here.
Keywords: appropriate scaffold; ala peptide; peptide appropriate; related peptide ... See more keywords