In Vitro Pharmacokinetic Optimizations of AM2-S31N Channel Blockers Led to the Discovery of Slow-Binding Inhibitors with Potent Antiviral Activity against Drug-Resistant Influenza A Viruses.
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DOI: 10.1021/acs.jmedchem.7b01536
Abstract: Influenza viruses are respiratory pathogens that are responsible for both seasonal influenza epidemics and occasional influenza pandemics. The narrow therapeutic window of oseltamivir, coupled with the emergence of drug resistance, calls for the next-generation of… read more here.
Keywords: s31n inhibitors; vitro pharmacokinetic; am2 s31n; influenza viruses ... See more keywords