Activation of the capsaicin‐receptor TRPV1 by the acetaminophen metabolite N‐arachidonoylaminophenol results in cytotoxicity
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DOI: 10.1016/j.lfs.2017.12.024
Abstract: Aims: The anandamide reuptake inhibitor N‐arachidonoylaminophenol (AM404) and the reactive substance N‐acetyl‐p‐benzoquinone imine (NAPQI) are both metabolites of acetaminophen and may contribute to acetaminophen‐induced analgesia by acting at TRPV1 expressed in the peripheral or central… read more here.
Keywords: trpv1; drg neurons; cytotoxicity; receptor ... See more keywords
Human sperm cells can form paracetamol metabolite AM404 that directly interferes with sperm calcium signalling and function through a CatSper-dependent mechanism.
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DOI: 10.1093/humrep/deac042
Abstract: STUDY QUESTION Do paracetamol (N-acetyl-para-aminophenol (APAP) or acetaminophen) and/or its metabolites affect human sperm Ca2+-signalling and function? SUMMARY ANSWER While APAP itself does not interact with Ca2+-signalling in human sperm, its metabolite N-arachidonoyl phenolamine (AM404),… read more here.
Keywords: function; apap; am404; sperm cells ... See more keywords