Epitope-based sieve analysis of Plasmodium falciparum sequences from a FMP2.1/AS02A vaccine trial is consistent with differential vaccine efficacy against immunologically relevant AMA1 variants.
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.06.035
Abstract: To prevent premature dismissal of promising vaccine programs, it is critical to determine if lack of efficacy in the field is due to allele specific-efficacy, rather than to the lack of immunogenicity of the candidate… read more here.
Keywords: ama1; trial; efficacy; fmp2 as02a ... See more keywords
Identification of adjuvants for clinical trials performed with Plasmodium falciparum AMA1 in rabbits
Sign Up to like & getrecommendations! Published in 2019 at "BMC Immunology"
DOI: 10.1186/s12865-019-0307-y
Abstract: BackgroundIn this study, seven adjuvants were compared for use with Plasmodium falciparum DiCo-Apical Membrane Antigen 1 (Pf-DiCo-AMA1), with the aim to identify an ideal adjuvant which yields high antibody titres and potentially broadens the responses… read more here.
Keywords: ama1; clinical trials; seven adjuvants; plasmodium falciparum ... See more keywords