Treatment of fatigue with methylphenidate, modafinil and amantadine in multiple sclerosis (TRIUMPHANT-MS): Study design for a pragmatic, randomized, double-blind, crossover clinical trial.
Sign Up to like & getrecommendations! Published in 2018 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2017.11.005
Abstract: BACKGROUND Fatigue is the most common symptom of multiple sclerosis (MS). Amantadine, modafinil and amphetamine-like stimulants are commonly used in clinical practice for treatment of fatigue; however, the evidence supporting their effectiveness is sparse and… read more here.
Keywords: trial; fatigue; amantadine; treatment ... See more keywords
A novel method based on Ag-Au nanorings with tunable plasmonic properties for the sensitive detection of amantadine.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2022.128498
Abstract: To prevent the toxic effect of amantadine (AMD) on humans, a sensitive and direct detection method is required. The conventional enzyme-linked immunosorbent assay (ELISA) usually shows a monochromatic gradient color variation with the concentration of… read more here.
Keywords: method; detection; naked eye; novel method ... See more keywords
On-line competitive host-guest interactions in a turn-on fluorometric method to amantadine determination in human serum and pharmaceutical formulations.
Sign Up to like & getrecommendations! Published in 2018 at "Talanta"
DOI: 10.1016/j.talanta.2017.10.064
Abstract: A competitive assay between the antiviral Amantadine and the dye Thionine for the Cucurbit[8]uril cavity was carried out in a flow injection analysis system for the indirect fluorescence detection of Amantadine. Both, Cucurbit[7]uril and Cucurbit[8]uril… read more here.
Keywords: methodology; amantadine; human serum; determination human ... See more keywords
Green in-Line Ion Selective Electrode Potentiometric Method for Determination of Amantadine in Dissolution Media and in Pharmaceutical Formulations
Sign Up to like & getrecommendations! Published in 2017 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.7b00421
Abstract: Amantadine HCl (AMN) is a well-known antiviral agent. Chemically, AMN chromophore privation leads to the absence of UV-absorbance, a condition that hinders direct spectrophotometric or simple chromatographic determination using common detectors without prior derivatization steps.… read more here.
Keywords: determination; amantadine; ion selective; ion ... See more keywords
Efficacy and safety of amantadine as a treatment for apathy after brain injury: Two single-case experimental design studies.
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychological rehabilitation"
DOI: 10.1080/09602011.2020.1842214
Abstract: Studies on the efficacy of amantadine as a treatment for apathy after brain injury are scarce and of low quality. We examined the efficacy and safety of amantadine for treatment of apathy in two individuals… read more here.
Keywords: brain injury; amantadine; amantadine treatment; case ... See more keywords
Amantadine Did Not Positively Impact Cognition in Chronic Traumatic Brain Injury: A Multi-Site, Randomized, Controlled Trial
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurotrauma"
DOI: 10.1089/neu.2018.5767
Abstract: Abstract Despite limited evidence to support the use of amantadine to enhance cognitive function after traumatic brain injury (TBI), the clinical use for this purpose is highly prevalent and is often based on inferred belief… read more here.
Keywords: index; amantadine; group; cognitive function ... See more keywords
Neuroprotective effects of amantadine for experimental acute carbon monoxide poisoning.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202210_29872
Abstract: OBJECTIVE Amantadine is known to have a neuroprotective effect in many neurological diseases. This study aims at investigating the neuroprotective effect of amantadine in rats exposed to carbon monoxide (CO) poisoning. MATERIALS AND METHODS Rats… read more here.
Keywords: amantadine; monoxide poisoning; group; carbon monoxide ... See more keywords
Comparison of LC-MS3 and LC-MRM Methods for Quantifying Amantadine and Its Application in Therapeutic Amantadine Monitoring in Human Plasma
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27217619
Abstract: A simple sample preprocessing method was developed for the quantitative determination of amantadine (AMT) in human plasma by liquid chromatography-tandem mass spectrometry cubed (LC-MS3). The LC-MS3 system comprised a Shimadzu Exion LC-20AD HPLC pump coupled… read more here.
Keywords: amantadine; human plasma; ms3; plasma ... See more keywords
Molecular docking investigation of the amantadine binding to the enzymes upregulated or downregulated in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2020 at "ADMET and DMPK"
DOI: 10.5599/admet.854
Abstract: Parkinson’s disease (PD) is a progressive neurodegenerative disease. Levodopa in combination with amantadine has a demonstrated efficacy in motility impairment. An extensive investigation of some enzymes described to be upregulated or downregulated in PD was… read more here.
Keywords: upregulated downregulated; amantadine; disease; investigation ... See more keywords