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   Articles with "amazonensis" as a keyword



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Leishmania amazonensis from distinct clinical forms/hosts has polymorphisms in Lipophosphoglycans, displays variations in immunomodulatory properties and, susceptibility to antileishmanial drugs

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recommendations! Published in 2022 at "Cell Biology International"

DOI: 10.1002/cbin.11880

Abstract: Lipophosphoglycan (LPG), the major Leishmania glycoconjugate, induces pro‐inflammatory/immunosuppressive innate immune responses. Here, we evaluated functional/biochemical LPG properties from six Leishmania amazonensis strains from different hosts/clinical forms. LPGs from three strains (GV02, BA276, and LV79) had… read more here.

Keywords: susceptibility antileishmanial; clinical forms; amazonensis; side chains ... See more keywords
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Synthesis, Biological Activity, and Mechanism of Action of 2‐Pyrazyl and Pyridylhydrazone Derivatives, New Classes of Antileishmanial Agents

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recommendations! Published in 2018 at "ChemMedChem"

DOI: 10.1002/cmdc.201800328

Abstract: In this work, we report the antileishmanial activity of 23 compounds based on 2‐pyrazyl and 2‐pyridylhydrazone derivatives. The compounds were tested against the promastigotes of Leishmania amazonensis and L. braziliensis, murine macrophages, and intracellular L. amazonensis amastigotes.… read more here.

Keywords: pyridylhydrazone derivatives; amazonensis; pyrazyl pyridylhydrazone; mechanism action ... See more keywords
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Interactions Between the Nematode Heterorhabditis amazonensis JPM4 and the Predator Macrolophus basicornis: Two Natural Enemies of Tuta absoluta Native to South America

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recommendations! Published in 2019 at "Neotropical Entomology"

DOI: 10.1007/s13744-019-00734-0

Abstract: Entomopathogenic nematodes (EPNs) and predatory mirids are among the most effective natural enemies for the control of Tuta absoluta, a key pest of tomato worldwide. In the case of South America, the native EPN Heterorhabditis… read more here.

Keywords: amazonensis; basicornis; predator; amazonensis jpm4 ... See more keywords
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Semicarbazone derivatives as promising therapeutic alternatives in leishmaniasis.

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recommendations! Published in 2019 at "Experimental parasitology"

DOI: 10.1016/j.exppara.2019.04.003

Abstract: In the present study, we investigated the in vitro and in vivo leishmanicidal activity of synthetic compounds, containing a semicarbazone scaffold as a peptide mimetic framework. The leishmanicidal effect against amastigotes of Leishmania amazonensis was… read more here.

Keywords: amazonensis; semicarbazone derivatives; leishmanicidal activity; activity ... See more keywords
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Efficacy of topical risedronate and risedronate - Eudragit E complex in a model of cutaneous leishmaniasis induced by Leishmania (Leishmania) amazonensis

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recommendations! Published in 2021 at "Heliyon"

DOI: 10.1016/j.heliyon.2021.e07136

Abstract: An efficacious topical treatment for cutaneous leishmaniasis (CL) is highly desirable but still an ongoing challenge. Systemic risedronate (Ris) has been reported to have anti-leishmanial properties and Eudragit EPO (EuE) has shown in vitro activity… read more here.

Keywords: amazonensis; efficacy topical; ris; risedronate ... See more keywords
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Activity of paromomycin against Leishmania amazonensis: Direct correlation between susceptibility in vitro and the treatment outcome in vivo

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recommendations! Published in 2020 at "International Journal for Parasitology: Drugs and Drug Resistance"

DOI: 10.1016/j.ijpddr.2020.08.001

Abstract: Paromomycin is an aminoglycoside antibiotic approved in 2006 for the treatment of visceral leishmaniasis caused by Leishmania donovani in Southeast Asia. Although this drug is not approved for the treatment of visceral and cutaneous leishmaniasis… read more here.

Keywords: leishmaniasis; amazonensis; susceptibility; vivo ... See more keywords
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Amentoflavone isolated from Selaginella sellowii Hieron induces mitochondrial dysfunction in Leishmania amazonensis promastigotes.

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recommendations! Published in 2021 at "Parasitology international"

DOI: 10.1016/j.parint.2021.102458

Abstract: Leishmaniasis chemotherapy is a bottleneck in disease treatment. Although available, chemotherapy is limited, toxic, painful, and does not lead to parasite clearance, with parasite resistance also being reported. Therefore, new therapeutic options are being investigated,… read more here.

Keywords: amazonensis; amentoflavone; leishmania amazonensis; mitochondrial dysfunction ... See more keywords
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Physicochemical and in vitro biological evaluations of furazolidone-based β-cyclodextrin complexes in Leishmania amazonensis.

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recommendations! Published in 2018 at "Research in veterinary science"

DOI: 10.1016/j.rvsc.2018.06.013

Abstract: Recently, there have been numerous cases of leishmaniasis reported in different Brazilian states. The use of furazolidone (FZD) to treat leishmaniasis has been previously described; however, the drug is associated with adverse effects such as… read more here.

Keywords: amazonensis; furazolidone based; vitro biological; evaluations furazolidone ... See more keywords
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Characterization of Leishmania (L.) amazonensis oligopeptidase B and its role in macrophage infection

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recommendations! Published in 2022 at "Parasitology"

DOI: 10.1017/s0031182022000816

Abstract: Abstract Abstract Leishmania spp. are parasitic protozoa that cause leishmaniasis, a disease endemic in 98 countries. Leishmania promastigotes are transmitted by the vector and differentiate into amastigotes within phagocytic cells of the vertebrate host. To… read more here.

Keywords: role; infection; leishmania; characterization leishmania ... See more keywords
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Antiparasitic Activity of Two Natural Terpenes from Salvia cuspidata against Leishmania amazonensis.

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recommendations! Published in 2023 at "Journal of natural products"

DOI: 10.1021/acs.jnatprod.2c00976

Abstract: Leishmaniasis is a neglected disease caused by flagellated parasites of the Leishmania genus affecting more than 10 million people worldwide. Current treatments for leishmaniasis involve the administration of poorly tolerated drugs with toxic side effects… read more here.

Keywords: salvia cuspidata; amazonensis; leishmania; activity ... See more keywords
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Effect of piplartine and cinnamides on Leishmania amazonensis, Plasmodium falciparum and on peritoneal cells of Swiss mice

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recommendations! Published in 2017 at "Pharmaceutical Biology"

DOI: 10.1080/13880209.2017.1313870

Abstract: Abstract Context: Plants of the Piperaceae family produce piplartine that was used to synthesize the cinnamides. Objective: To assess the effects of piplartine (1) and cinnamides (2–5) against the protozoa responsible for malaria and leishmaniasis,… read more here.

Keywords: amazonensis; peritoneal cells; falciparum; cells swiss ... See more keywords