Chitosan functionalized poly (ε-caprolactone) nanoparticles for amphotericin B delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2018.08.142
Abstract: Amphotericin B (AmB) is a broad-spectrum antifungal drug used in the treatment of fungal invasive infections. However, its clinical use has been limited due to its side effects and toxicity, especially the nephrotoxicity. Furthermore, AmB… read more here.
Keywords: caprolactone nanoparticles; chitosan functionalized; delivery; poly caprolactone ... See more keywords
Linolenic acid-modified methoxy poly (ethylene glycol)-oligochitosan conjugate micelles for encapsulation of amphotericin B.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2018.10.086
Abstract: Introduction of linolenic acid (LNA) and methoxy poly (ethylene glycol) (MPEG) to the backbone of oligochitosan (CS) afforded LNA-modified MPEG-CS conjugate (MPEG-CS-LNA). Amphotericin B-loaded MPEG-CS-LNA micelles (AmB-M) were prepared via dialysis method with 82.27 ± 1.96% of… read more here.
Keywords: methoxy poly; linolenic acid; lna; poly ethylene ... See more keywords
Iron uptake and magnetite biomineralization in the magnetotactic bacterium Magnetospirillum magneticum strain AMB-1: An iron isotope study
Sign Up to like & getrecommendations! Published in 2018 at "Geochimica et Cosmochimica Acta"
DOI: 10.1016/j.gca.2018.04.020
Abstract: Abstract Magnetotactic bacteria (MTB) produce intracellular, membrane-bounded magnetite [Fe(II)Fe(III)2O4] crystals in a genetically controlled way. They are ubiquitous in aquatic environments, and have been proposed to represent some of the most ancient biomineralizing organisms on… read more here.
Keywords: iii; isotope; strain amb; uptake magnetite ... See more keywords
Development of a topical liposomal formulation of Amphotericin B for the treatment of cutaneous leishmaniasis
Sign Up to like & getrecommendations! Published in 2019 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2019.09.004
Abstract: Background Currently, there is no topical treatment available for any form of cutaneous leishmaniasis (CL) in most of the endemic areas. The aim of the current study was to develop a topical nano-liposomal Amphotericin B… read more here.
Keywords: cutaneous leishmaniasis; treatment; lip amb; amb ... See more keywords
Optimization, stabilization, and characterization of amphotericin B loaded nanostructured lipid carriers for ocular drug delivery.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118771
Abstract: The current study sought to formulate, optimize, and stabilize amphotericin B (AmB) loaded PEGylated nanostructured lipid carriers (NLC) and to study its ocular biodistribution following topical instillation. AmB loaded PEGylated NLC (AmB-PEG-NLC) were fabricated by… read more here.
Keywords: peg2k nlc; amb peg2k; drug; amb ... See more keywords
Nanostructured lipid carriers containing Amphotericin B: Development, in vitro release assay, and storage stability
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2018.10.003
Abstract: Abstract Nanostructured-lipid-carriers (NLC) can improve the encapsulation rate and the stability of drugs. The aim of this study was to develop an amphotericin B (AmB)-containing-NLC (AmB-NLC). An experimental design was applied in order to determine… read more here.
Keywords: lipid carriers; vitro release; stability; amb ... See more keywords
Bioanalysis of free and liposomal Amphotericin B in rat plasma using solid phase extraction and protein precipitation followed by LC‐MS/MS
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.06.014
Abstract: HIGHLIGHTSFree and liposomal Amphotericin B were effectively separated in rat plasma by solid phase extraction without liposomal breakdown.Liposomal Amphotericin B was quantified by calculating the difference between total and free Amphotericin B.The method was successfully… read more here.
Keywords: rat plasma; amphotericin; phase extraction; liposomal amphotericin ... See more keywords
The Perpendicular Orientation of Amphotericin B Methyl Ester in Hydrated Lipid Bilayers Supports the Barrel-Stave Model.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00180
Abstract: The clinically important antibiotic amphotericin B (AmB) is a membrane-active natural product that targets membrane sterol. The antimicrobial activity of AmB is generally attributed to its membrane permeabilization, which occurs when a pore is formed… read more here.
Keywords: supports barrel; barrel stave; stave model; amb ... See more keywords
Enhancing safety and efficacy by altering the toxic aggregated state of Amphotericin B in lipidic nanoformulations.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c00313
Abstract: The toxicity of Amphotericin B (AmB) is contributed by the small, water-soluble aggregates of the drug. Hence, AmB lipid polymer hybrid nanoparticles (LIPOMER), comprising of stearate lipids with a hydrophilic polymer Gantrez (GZ), and solid… read more here.
Keywords: safety efficacy; efficacy; toxic aggregated; altering toxic ... See more keywords
Enhancement of the Antifungal Activity of Chitinase by Palmitoylation and the Synergy of Palmitoylated Chitinase with Amphotericin B.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00052
Abstract: Combinations of antifungal drugs can have synergistic antifungal activity, achieving high therapeutic efficacy while minimizing the side effects. Amphotericin B (AMB) has been used as a standard antifungal drug for fungal infections; however, because of… read more here.
Keywords: antifungal activity; chitinase; lysm pal; lysm ... See more keywords
Amphotericin B Tamed by Salicylic Acid
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c07201
Abstract: Although Amphotericin B (AmB) is considered as the “gold standard” treatment for deep fungal infections, owing to its excellent antifungal effect, it often causes severe hemolytic toxicity and nephrotoxicity, which limits its clinical use. We… read more here.
Keywords: amphotericin tamed; tamed salicylic; amb; salicylic acid ... See more keywords