Epigenetics in developmental defects of enamel:A scoping review.
Sign Up to like & getrecommendations! Published in 2023 at "Oral diseases"
DOI: 10.1111/odi.14568
Abstract: OBJECTIVES The significant role of epigenetics has been revealed in normal enamel formation process and occurrence of developmental defects. This presented literature is aiming at summarizing the regulatory function of epigenetics in physiological amelogenesis process… read more here.
Keywords: amelogenesis; epigenetics developmental; review; defects enamel ... See more keywords
Autophagy Plays a Crucial Role in Ameloblast Differentiation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of dental research"
DOI: 10.1177/00220345231169220
Abstract: Tooth enamel is generated by ameloblasts. Any failure in amelogenesis results in defects in the enamel, a condition known as amelogenesis imperfecta. Here, we report that mice with deficient autophagy in epithelial-derived tissues (K14-Cre;Atg7F/F and… read more here.
Keywords: amelogenesis imperfecta; amelogenesis; ameloblast differentiation; autophagy ... See more keywords
FAM20A Gene Mutation: Amelogenesis or Ectopic Mineralization?
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2017.00267
Abstract: Background and objective: FAM20A gene mutations result in enamel renal syndrome (ERS) associated with amelogenesis imperfecta (AI), nephrocalcinosis, gingival fibromatosis, and impaired tooth eruption. FAM20A would control the phosphorylation of enamel peptides and thus enamel… read more here.
Keywords: mineralization; amelogenesis; fam20a gene; ectopic mineralization ... See more keywords
Amelogenesis Imperfecta; Genes, Proteins, and Pathways
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DOI: 10.3389/fphys.2017.00435
Abstract: Amelogenesis imperfecta (AI) is the name given to a heterogeneous group of conditions characterized by inherited developmental enamel defects. AI enamel is abnormally thin, soft, fragile, pitted and/or badly discolored, with poor function and aesthetics,… read more here.
Keywords: amelogenesis; isolation health; presenting isolation; amelogenesis imperfecta ... See more keywords
Amelogenesis imperfecta: Next-generation sequencing sheds light on Witkop’s classification
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1130175
Abstract: Amelogenesis imperfecta (AI) is a heterogeneous group of genetic rare diseases disrupting enamel development (Smith et al., Front Physiol, 2017a, 8, 333). The clinical enamel phenotypes can be described as hypoplastic, hypomineralized or hypomature and… read more here.
Keywords: witkop classification; amelogenesis imperfecta; amelogenesis; next generation ... See more keywords