Amentoflavone Ameliorates Memory Deficits and Abnormal Autophagy in Aβ25-35-Induced Mice by mTOR Signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-020-03223-8
Abstract: Alzheimer's disease (AD) is a neurodegenerative disease in which autophagy plays a crucial role. Amentoflavone is a flavonoid obtained from various plants and has been shown to have AD-resistant neuroprotective effects. This study investigated the… read more here.
Keywords: amentoflavone; induced mice; mtor; autophagy ... See more keywords
Amentoflavone protects the hematopoietic system of mice against γ-irradiation.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of pharmacal research"
DOI: 10.1007/s12272-019-01187-0
Abstract: Some flavonoids have been shown to exhibit good antioxidant activity and protect mice from damage induced by radiation. Amentoflavone (AMF), a biflavonoid derived from the traditional herb-Selaginella tamariscina, has been reported to have antioxidant properties.… read more here.
Keywords: irradiation; system; hematopoietic system; amentoflavone ... See more keywords
Amentoflavone isolated from Selaginella sellowii Hieron induces mitochondrial dysfunction in Leishmania amazonensis promastigotes.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology international"
DOI: 10.1016/j.parint.2021.102458
Abstract: Leishmaniasis chemotherapy is a bottleneck in disease treatment. Although available, chemotherapy is limited, toxic, painful, and does not lead to parasite clearance, with parasite resistance also being reported. Therefore, new therapeutic options are being investigated,… read more here.
Keywords: amazonensis; amentoflavone; leishmania amazonensis; mitochondrial dysfunction ... See more keywords
Amentoflavone inhibits hepatitis B virus infection via the suppression of preS1 binding to host cells.
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology and immunology"
DOI: 10.1111/1348-0421.13064
Abstract: Hepatitis B virus (HBV) is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Current therapeutic drugs for chronic HBV infection use interferon and nucleos(t)ide analogues; however, their efficacy is limited. Thus, there… read more here.
Keywords: amentoflavone inhibits; anti hbv; hbv; amentoflavone ... See more keywords
Anticancer Efficacy and Mechanism of Amentoflavone for Sensitizing Oral Squamous Cell Carcinoma to Cisplatin
Sign Up to like & getrecommendations! Published in 2020 at "AntiCancer Research"
DOI: 10.21873/anticanres.14695
Abstract: Background/Aim: Nuclear factor kappa B (NF-κB) inactivation and apoptosis activation have been shown to enhance the anticancer effect of cisplatin in oral squamous cell carcinoma (OSCC). Amentoflavone may suppress NF-κB activity and trigger apoptosis in… read more here.
Keywords: mechanism amentoflavone; amentoflavone; cisplatin; anticancer ... See more keywords
Reinforcement of Sorafenib Anti-osteosarcoma Effect by Amentoflavone Is Associated With the Induction of Apoptosis and Inactivation of ERK/NF-κB
Sign Up to like & getrecommendations! Published in 2022 at "In Vivo"
DOI: 10.21873/invivo.12812
Abstract: Background/Aim: Sorafenib has been reported to show anti-osteosarcoma (anti-OS) efficacy by inhibiting metastasis; however, a phase II trial suggested that further combination with other agents could be necessary to achieve permanent remission. Herein, we aimed… read more here.
Keywords: amentoflavone; reinforcement sorafenib; apoptosis; anti osteosarcoma ... See more keywords
Amentoflavone as an Ally in the Treatment of Cutaneous Leishmaniasis: Analysis of Its Antioxidant/Prooxidant Mechanisms
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.615814
Abstract: Treatment of leishmaniasis is a challenging subject. Although available, chemotherapy is limited, presenting toxicity and adverse effects. New drugs with antileishmanial activity are being investigated, such as antiparasitic compounds derived from plants. In this work,… read more here.
Keywords: treatment cutaneous; amentoflavone; antioxidant prooxidant; treatment ... See more keywords
Amentoflavone Affects Epileptogenesis and Exerts Neuroprotective Effects by Inhibiting NLRP3 Inflammasome
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00856
Abstract: Brain inflammation is one of the main causes of epileptogenesis, a chronic process triggered by various insults, including genetic or acquired factors that enhance susceptibility to seizures. Amentoflavone, a naturally occurring biflavonoid compound that has… read more here.
Keywords: exerts neuroprotective; epileptogenesis; neuroprotective effects; inhibiting nlrp3 ... See more keywords
Antidiabetic Activity and Potential Mechanism of Amentoflavone in Diabetic Mice
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24112184
Abstract: Aim: To investigate the anti-diabetic activity of amentoflavone (AME) in diabetic mice, and to explore the potential mechanisms. Methods: Diabetic mice induced by high fat diet and streptozotocin were administered with amentoflavone for 8 weeks.… read more here.
Keywords: antidiabetic activity; amentoflavone; anti diabetic; diabetic mice ... See more keywords