Abstract 516: Discovery and preclinical characterization of AMG 650, a first-in-class inhibitor of kinesin KIF18A motor protein with potent activity against chromosomally unstable cancers
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DOI: 10.1158/1538-7445.am2023-516
Abstract: Chromosomal instability (CIN) is a hallmark of human cancers and is caused by persistent errors in chromosome segregation during mitosis. Aggressive types of human cancer such as high-grade serous ovarian cancer and triple-negative breast cancer… read more here.
Keywords: inhibitor; amg 650; kif18a; motor ... See more keywords