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   Articles with "amidation" as a keyword



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Unveiling the reaction process of the amine in direct amidation of aromatic ketones in H2O

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recommendations! Published in 2020 at "ChemistryOpen"

DOI: 10.1002/open.202000178

Abstract: Abstract In the classical amidation between aromatic ketones and amines, 2.0 equivalents of amines are necessarily required to gain satisfying yields. The specific role of the amine in the direct amidation already puzzled us for… read more here.

Keywords: aromatic ketones; amine direct; direct amidation; amine ... See more keywords
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Methionine‐associated peptide α‐amidation is directed both to the N‐ and the C‐terminal amino acids

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recommendations! Published in 2022 at "Journal of Peptide Science"

DOI: 10.1002/psc.3429

Abstract: Peptide‐bound methionine may transfer oxidative damage from the thioether side chain to the peptide backbone, catalyzing decomposition in general and α‐amidation in particular. In the present study, we focused on the reactivity and reaction pathways… read more here.

Keywords: amidation; methionine; directed amidation; terminus directed ... See more keywords
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On-tissue amidation of sialic acid with aniline for sensitive imaging of sialylated N-glycans from FFPE tissue sections via MALDI mass spectrometry

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recommendations! Published in 2022 at "Analytical and Bioanalytical Chemistry"

DOI: 10.1007/s00216-022-03894-y

Abstract: Spatial visualization of glycans within clinical tissue samples is critical for discovery of disease-relevant glycan dysregulations. Herein, we develop an on-tissue derivatization strategy for sensitive spatial visualization of N-glycans from formalin-fixed paraffin-embedded (FFPE) tissue sections,… read more here.

Keywords: tissue sections; tissue; sialic acid; amidation ... See more keywords
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Repurposing n-butyl stannoic acid as highly efficient catalyst for direct amidation of carboxylic acids with amines

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recommendations! Published in 2018 at "Tetrahedron Letters"

DOI: 10.1016/j.tetlet.2018.11.036

Abstract: Abstract This is the first-time report on the repurposing n-butyl stannoic acid as a catalyst for direct amidation of carboxylic acids with amines. Notably, efficient amidation observed in comparison with all other catalytic methods reported… read more here.

Keywords: butyl stannoic; catalyst direct; stannoic acid; repurposing butyl ... See more keywords
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DNA Compatible Oxidization and Amidation of Terminal Alkynes.

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recommendations! Published in 2022 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.2c00340

Abstract: Through a modified Kinugasa reaction, a novel method of amidation on terminal oligo alkyne conjugates by copper-promoted oxidation with nitrones has been developed. Unprotected bifunctional carboxylic acid-amine reagents can be transformed directly to the respective… read more here.

Keywords: amidation terminal; dna compatible; compatible oxidization; terminal alkynes ... See more keywords
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Methyltrimethoxysilane (MTM) as a Reagent for Direct Amidation of Carboxylic Acids.

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recommendations! Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.1c04265

Abstract: Methyltrimethoxysilane [MTM, CH3Si(OMe)3] has been demonstrated to be an effective, inexpensive, and safe reagent for the direct amidation of carboxylic acids with amines. Two simple workup procedures that provide the pure amide product without the… read more here.

Keywords: reagent direct; direct amidation; carboxylic acids; amidation carboxylic ... See more keywords
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Iridium-Catalyzed Amidation of In Situ Prepared Silyl Ketene Acetals to Access α-Amino Esters.

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recommendations! Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.1c04376

Abstract: Disclosed herein is a convenient Ir-catalyzed amidation of esters to access α-amido esters. Initially prepared silyl ketene acetals are directly employed, without separate purification, for subsequent amidation with an oxycarbonylnitrenoid precursor using the Cp*(LX)Ir(III) catalyst.… read more here.

Keywords: catalyzed amidation; silyl ketene; ketene acetals; access ... See more keywords
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1,2-Diamines as the Amine Sources in Amidation and Rhodium-Catalyzed Asymmetric Reductive Amination Cascade Reactions.

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recommendations! Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.2c01728

Abstract: The sturdy chelation of 1,2-diamines and transition-metals would retard or even interrupt the routine catalytic cycles. In the amidation and asymmetric reductive amination (ARA) cascade reactions of diamines and ketoesters, we deployed sets of additives… read more here.

Keywords: asymmetric reductive; reductive amination; amidation; cascade reactions ... See more keywords
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Cobalt(III)- and Rhodium(III)-Catalyzed C-H Amidation and Synthesis of 4-Quinolones: C-H Activation Assisted by Weakly Coordinating and Functionalizable Enaminone.

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recommendations! Published in 2017 at "Organic letters"

DOI: 10.1021/acs.orglett.7b00583

Abstract: Cobalt(III) and rhodium(III) catalysts exhibited complementary scope in C-H amidation of aryl enaminones. The amidation reactions proceeded with broad scope under the assistance of a weakly coordinating and bifunctional enaminone directing group. The electrophilicity of… read more here.

Keywords: weakly coordinating; enaminone; iii rhodium; cobalt iii ... See more keywords
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Dichotomy of Atom-Economical Hydrogen-Free Reductive Amidation vs Exhaustive Reductive Amination.

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recommendations! Published in 2017 at "Organic letters"

DOI: 10.1021/acs.orglett.7b02821

Abstract: Rh-catalyzed one-step reductive amidation of aldehydes has been developed. The protocol does not require an external hydrogen source and employs carbon monoxide as a deoxygenative agent. The direction of the reaction can be altered simply… read more here.

Keywords: dichotomy atom; economical hydrogen; atom economical; amidation ... See more keywords
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Synthesis of Sultams and Cyclic N-Sulfonyl Ketimines via Iron-Catalyzed Intramolecular Aliphatic C-H Amidation.

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recommendations! Published in 2019 at "Organic letters"

DOI: 10.1021/acs.orglett.9b01732

Abstract: Cyclic sulfonamides (sultams) play a unique role in drug discovery and synthetic chemistry. A direct synthesis of sultams by an intramolecular C(sp3)-H amidation reaction using an iron complex in situ derived from Fe(ClO4)2 and aminopyridine… read more here.

Keywords: iron catalyzed; synthesis sultams; cyclic sulfonyl; iron ... See more keywords