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   Articles with "amidation" as a keyword



Copper‐Promoted Oxidative Amidation of Imines: A Facile Route to Amides

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recommendations! Published in 2024 at "European Journal of Organic Chemistry"

DOI: 10.1002/ejoc.202400315

Abstract: Herein, an environmentally friendly and efficient amidation method of imines by Oxone and CuO has been developed. This facile method shows excellent selectivity without affecting other functional groups such as phenyls, halogens, cyans, esters or… read more here.

Keywords: amidation; amidation imines; oxidative amidation; promoted oxidative ... See more keywords

Amidation of β‐Keto Sulfonyl Fluorides via C–C Bond Cleavage

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recommendations! Published in 2024 at "European Journal of Organic Chemistry"

DOI: 10.1002/ejoc.202400391

Abstract: A simple protocol for amide bond construction using β‐keto sulfonyl fluorides (BKSFs) as the acyl surrogates has been achieved. The reaction of BKSFs with a range of amines could be performed in presence of N‐bromosuccinimide… read more here.

Keywords: keto sulfonyl; sulfonyl; sulfonyl fluorides; bond ... See more keywords

Unveiling the reaction process of the amine in direct amidation of aromatic ketones in H2O

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recommendations! Published in 2020 at "ChemistryOpen"

DOI: 10.1002/open.202000178

Abstract: Abstract In the classical amidation between aromatic ketones and amines, 2.0 equivalents of amines are necessarily required to gain satisfying yields. The specific role of the amine in the direct amidation already puzzled us for… read more here.

Keywords: aromatic ketones; amine direct; direct amidation; amine ... See more keywords

Methionine‐associated peptide α‐amidation is directed both to the N‐ and the C‐terminal amino acids

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recommendations! Published in 2022 at "Journal of Peptide Science"

DOI: 10.1002/psc.3429

Abstract: Peptide‐bound methionine may transfer oxidative damage from the thioether side chain to the peptide backbone, catalyzing decomposition in general and α‐amidation in particular. In the present study, we focused on the reactivity and reaction pathways… read more here.

Keywords: amidation; methionine; directed amidation; terminus directed ... See more keywords

The emergence of sulfo-click amidation in kinetic target-guided synthesis

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recommendations! Published in 2024 at "Medicinal Chemistry Research"

DOI: 10.1007/s00044-024-03236-w

Abstract: Sulfo-click is a chemoselective and biocompatible reaction between thioacids and sulfonyl azides that forms highly versatile N-acylsulfonamides, interesting bioisosteres of carboxylic acids. This reaction is useful for chemists and biologists and has many applications in… read more here.

Keywords: chemistry; target guided; sulfo click; guided synthesis ... See more keywords

On-tissue amidation of sialic acid with aniline for sensitive imaging of sialylated N-glycans from FFPE tissue sections via MALDI mass spectrometry

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recommendations! Published in 2022 at "Analytical and Bioanalytical Chemistry"

DOI: 10.1007/s00216-022-03894-y

Abstract: Spatial visualization of glycans within clinical tissue samples is critical for discovery of disease-relevant glycan dysregulations. Herein, we develop an on-tissue derivatization strategy for sensitive spatial visualization of N-glycans from formalin-fixed paraffin-embedded (FFPE) tissue sections,… read more here.

Keywords: tissue sections; tissue; sialic acid; amidation ... See more keywords

Repurposing n-butyl stannoic acid as highly efficient catalyst for direct amidation of carboxylic acids with amines

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recommendations! Published in 2018 at "Tetrahedron Letters"

DOI: 10.1016/j.tetlet.2018.11.036

Abstract: Abstract This is the first-time report on the repurposing n-butyl stannoic acid as a catalyst for direct amidation of carboxylic acids with amines. Notably, efficient amidation observed in comparison with all other catalytic methods reported… read more here.

Keywords: butyl stannoic; catalyst direct; stannoic acid; repurposing butyl ... See more keywords

DNA Compatible Oxidization and Amidation of Terminal Alkynes.

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recommendations! Published in 2022 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.2c00340

Abstract: Through a modified Kinugasa reaction, a novel method of amidation on terminal oligo alkyne conjugates by copper-promoted oxidation with nitrones has been developed. Unprotected bifunctional carboxylic acid-amine reagents can be transformed directly to the respective… read more here.

Keywords: amidation terminal; dna compatible; compatible oxidization; terminal alkynes ... See more keywords

Methyltrimethoxysilane (MTM) as a Reagent for Direct Amidation of Carboxylic Acids.

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recommendations! Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.1c04265

Abstract: Methyltrimethoxysilane [MTM, CH3Si(OMe)3] has been demonstrated to be an effective, inexpensive, and safe reagent for the direct amidation of carboxylic acids with amines. Two simple workup procedures that provide the pure amide product without the… read more here.

Keywords: reagent direct; direct amidation; carboxylic acids; amidation carboxylic ... See more keywords

Iridium-Catalyzed Amidation of In Situ Prepared Silyl Ketene Acetals to Access α-Amino Esters.

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recommendations! Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.1c04376

Abstract: Disclosed herein is a convenient Ir-catalyzed amidation of esters to access α-amido esters. Initially prepared silyl ketene acetals are directly employed, without separate purification, for subsequent amidation with an oxycarbonylnitrenoid precursor using the Cp*(LX)Ir(III) catalyst.… read more here.

Keywords: catalyzed amidation; silyl ketene; ketene acetals; access ... See more keywords

1,2-Diamines as the Amine Sources in Amidation and Rhodium-Catalyzed Asymmetric Reductive Amination Cascade Reactions.

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recommendations! Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.2c01728

Abstract: The sturdy chelation of 1,2-diamines and transition-metals would retard or even interrupt the routine catalytic cycles. In the amidation and asymmetric reductive amination (ARA) cascade reactions of diamines and ketoesters, we deployed sets of additives… read more here.

Keywords: asymmetric reductive; reductive amination; amidation; cascade reactions ... See more keywords