Multifunctional catalysis: stereoselective construction of α-methylidene-γ-lactams via an amidation/Rauhut-Currier sequence.
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DOI: 10.1039/c7cc02839c
Abstract: Mixing of acryloylchloride, dienone 2, N,N-diisopropylethylamine with chiral organocatalyst 5a, which could simultaneously act as Brønsted and Lewis base catalysts, led to a one-pot amidation/Rauhut-Currier sequence, affording α-methylidene-γ-lactams 4. Catalyst 5a could be recovered and… read more here.
Keywords: amidation rauhut; methylidene lactams; rauhut currier; currier sequence ... See more keywords