On the Origin of Rh-Catalyzed Selective Ring-Opening Amidation of Substituted Cyclopropanols to Access β2-Amino Ketones.
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DOI: 10.1021/jacs.1c12934
Abstract: β2-Amino carbonyls, an α-substituted β-amino scaffold, hold a prominent place in the development of new pharmaceuticals and peptidomimetics. Herein, we report a highly efficient Rh-catalyzed ring-opening amidation of substituted cyclopropanols, which turned out to serve… read more here.
Keywords: amidation substituted; substituted cyclopropanols; amino ketones; amino ... See more keywords