Analysis of adsorption energy distribution in selected hydrophilic-interaction chromatography systems with amide, amine and zwitterionic stationary phases.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of separation science"
DOI: 10.1002/jssc.202100160
Abstract: Adsorption mechanism of caffeine, quercetin and phenol as test substances in various chromatographic systems have been analyzed. The investigations were conducted using three different chromatographic columns packed with polar bonded stationary phases, i.e. amide, amine… read more here.
Keywords: adsorption; adsorption energy; energy; amine zwitterionic ... See more keywords
Amide-Amine Replacement in Indole-2-carboxamides Yields Potent Mycobactericidal Agents with Improved Water Solubility.
Sign Up to like & getrecommendations! Published in 2021 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.0c00588
Abstract: Indolecarboxamides are potent but poorly soluble mycobactericidal agents. Here we found that modifying the incipient scaffold by amide-amine substitution and replacing the indole ring with benzothiophene or benzoselenophene led to striking (10-20-fold) improvements in solubility.… read more here.
Keywords: indole carboxamides; carboxamides yields; amine replacement; amide amine ... See more keywords