1,4‐Dihydropyridinebutyrolactone‐derived ring‐opened ester and amide analogs targeting BET bromodomains
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DOI: 10.1002/ardp.202200288
Abstract: Based on a previously reported 1,4‐dihydropyridinebutyrolactone virtual screening hit, nine lactone ring‐opened ester and seven amide analogs were prepared. The analogs were designed to provide interactions with residues at the entrance of the ZA loop… read more here.
Keywords: bet; bet bromodomains; amide analogs; opened ester ... See more keywords
Synthesis and evaluation of potent yaku'amide A analogs
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DOI: 10.1039/d1sc05992k
Abstract: Two full-length analogs of the anticancer peptide yaku'amide A (1a) and four partial structures have been synthesized. These analogs were identified by computational studies in which the three E- and Z-ΔIle residues of the natural… read more here.
Keywords: synthesis evaluation; amide analogs; synthesis; yaku amide ... See more keywords