Synthesis and evaluation of novel urea and amide derivatives of 2-amino-4-phenylthiazole as potential antibacterial agents
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1910-1
Abstract: Two series of novel urea- and amide-functionalized 2,4-disubstituted thiazole derivatives were efficiently synthesized and characterized by 1H nuclear magnetic resonance, 13C nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The target compounds were evaluated for… read more here.
Keywords: amide derivatives; novel urea; antibacterial activity; activity ... See more keywords
Design, synthesis and biological evaluation of (E)-3-(3,4,5-trimethoxyphenyl) acrylic acid (TMCA) amide derivatives as anticonvulsant and sedative agents
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-018-2228-3
Abstract: In this article, a novel series of (E)-3-(3,4,5-trimethoxyphenyl)acrylic acid (TMCA) amide derivatives 1-18 were designed and synthesized by a facile and one-pot step, which were achieved with good yields using 1-hydroxybenzotriazole (HOBT) and 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride… read more here.
Keywords: amide derivatives; anticonvulsant sedative; acrylic acid; tmca amide ... See more keywords
Antibacterial Activity of Novel 18β-Glycyrrhetinic Hydrazide or Amide Derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-021-0370-9
Abstract: Through a facile structural modification on the natural bioactive ingredient 18β-glycyrrhetinic acid(GA), a series of novel GA hydrazide or amide derivatives was obtained, and their final molecular frameworks were characterized by NMR and HRMS analysis.… read more here.
Keywords: amide derivatives; antibacterial activity; hydrazide amide; activity novel ... See more keywords
Novel amide derivatives containing an imidazo[1,2-a]pyridine moiety: Design, synthesis as potential nematicidal and antibacterial agents.
Sign Up to like & getrecommendations! Published in 2021 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2021.104857
Abstract: To discover new nematicides, a series of novel amide derivatives containing an imidazo[1,2-a]pyridine moeity were designed and synthesized. Among the title compounds, compounds 3 and 27 exhibited good nematicidal activities against Aphelenchoides besseyi (rice white-tip… read more here.
Keywords: amide derivatives; novel amide; imidazo pyridine; derivatives containing ... See more keywords
Design, synthesis and antiproliferative effect of 17β-amide derivatives of 2-methoxyestradiol and their studies on pharmacokinetics
Sign Up to like & getrecommendations! Published in 2017 at "Steroids"
DOI: 10.1016/j.steroids.2017.09.013
Abstract: Graphical abstract Figure. No Caption available. HighlightsFirst reported 17&bgr;‐amide derivatives of 2‐methoxyestradiol.The single crystal X‐ray diffraction confirmed the configuration of 17&bgr;‐butyrylamino of 6c.Three derivatives had similar or even better effects than 2‐ME in antiproliferative assay.Pharmacokinetic… read more here.
Keywords: amide derivatives; bgr; derivatives methoxyestradiol; antiproliferative effect ... See more keywords
Construction, Pesticidal Activities, Control Effects, and Detoxification Enzyme Activities of Osthole Ester/Amide Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02534
Abstract: Pesticide research and development has entered an era of safety, efficiency, and environmental friendliness. Discovery of effective active products directly or indirectly from plant secondary metabolites as pesticide candidates has been one of the current… read more here.
Keywords: ester amide; detoxification enzyme; construction pesticidal; amide derivatives ... See more keywords
Synthesis, Insecticidal Activities, and 3D-QASR of N-Pyridylpyrazole Amide Derivatives Containing a Phthalimide as Potential Ryanodine Receptor Activators.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c03971
Abstract: To develop potent and environment-friendly insecticides, novel N-pyridylpyrazole amide derivatives containing a phthalimide were designed and synthesized. The preliminary bioassay results showed that most of the target compounds exhibited good insecticidal activities. For oriental armyworm… read more here.
Keywords: containing phthalimide; derivatives containing; pyridylpyrazole amide; amide derivatives ... See more keywords
Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies
Sign Up to like & getrecommendations! Published in 2020 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.9b00666
Abstract: An agonist–antagonist switching strategy was performed to discover novel PPARα antagonists. Phenyldiazenyl derivatives of fibrates were developed, bearing sulfonimide or amide functional groups. A second series of compounds was synthesized, replacing the phenyldiazenyl moiety with… read more here.
Keywords: amide derivatives; novel ppar; ppar antagonists; sulfonimide amide ... See more keywords
Amide derivatives of 4-azaindole: Design, synthesis, and EGFR targeting anticancer agents
Sign Up to like & getrecommendations! Published in 2019 at "Synthetic Communications"
DOI: 10.1080/00397911.2019.1683206
Abstract: Abstract A series of amide derivatives of azaindole-oxazoles (11a-n) were designed and synthesized and their structures were confirmed by 1HNMR, 13CNMR and mass spectral analysis. Further, these derivatives were screened for their anticancer activity against… read more here.
Keywords: design synthesis; azaindole design; amide derivatives; derivatives azaindole ... See more keywords
Synthesis and Biological Evaluation of Amide Derivatives of Imidazopyridine as Anticancer Agents
Sign Up to like & getrecommendations! Published in 2019 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363219070193
Abstract: A series of new amide derivatives of imidazopyridine is synthesized and structures of the products are confirmed by 1H and 13C NMR, and mass spectral data. The synthesized derivatives are screened for their anticancer activity… read more here.
Keywords: synthesis biological; biological evaluation; amide derivatives; derivatives imidazopyridine ... See more keywords
Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052601
Abstract: Background: Very few papers covering the anticancer activity of azulenes have been reported, as compared with those of antibacterial and anti-inflammatory activity. This led us to investigate the antitumor potential of fifteen 4,6,8-trimethyl azulene amide… read more here.
Keywords: trimethyl azulene; amide derivatives; activity; tumor specificity ... See more keywords