Two Directing Groups Used for Metal Catalysed Meta‐C−H Functionalisation Only Effect Ortho Electrophilic C−H Borylation
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202200901
Abstract: Abstract Two templates used in meta‐directed C−H functionalisation under metal catalysis do not direct meta‐C−H borylation under electrophilic borylation conditions. Using BCl3 only Lewis adduct formation with Lewis basic sites in the template is observed.… read more here.
Keywords: meta borylation; ortho borylation; meta; borylation ... See more keywords
α-Amidoboronate esters by amide-directed alkane C H borylation
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.03.020
Abstract: Abstract α-Amidoboronic acids have received significant attention in recent years following the development of Bortezomib as an FDA-approved treatment of multiple myeloma and mantle cell lymphoma. More versatile methods to access α-amidoboronic acids continue to… read more here.
Keywords: directed alkane; amidoboronic acids; amide directed; esters amide ... See more keywords
Mechanism-Based Design of an Amide-Directed Ni-Catalyzed Arylboration of Cyclopentene Derivatives.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.0c04208
Abstract: A method for amide-directed Ni-catalyzed diastereoselective arylboration of cyclopentenes is disclosed. The reaction allows for the synthesis of sterically congested cyclopentane scaffolds that contain an easily derivatized boronic ester and amide functional handles. The nature… read more here.
Keywords: amide directed; arylboration; design amide; based design ... See more keywords
Amide-Directed Cobalt(III)-Catalyzed C-H Amidation of Ferrocenes.
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DOI: 10.1021/acs.orglett.8b03938
Abstract: The amide-directed cobalt(III)-catalyzed C-H amidation of ferrocene carboxamides using 1,4,2-dioxazol-5-ones as robust and efficient amidating reagents has been developed. This reaction proceeds efficiently under mild reaction conditions with good functional group tolerance, providing expedient access… read more here.
Keywords: amide directed; catalyzed amidation; directed cobalt; iii catalyzed ... See more keywords
Remote Stereocenter through Amide-Directed, Rhodium-Catalyzed Enantioselective Hydroboration of Unactivated Internal Alkenes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c05993
Abstract: Despite the frequent occurrence of γ-branched amines in bioactive molecules, the direct catalytic asymmetric synthesis of this structural motif containing a remote stereocenter remains an important synthetic challenge. Here, we report an amide-directed, rhodium-catalyzed highly… read more here.
Keywords: directed rhodium; remote stereocenter; enantioselective hydroboration; rhodium ... See more keywords