More than π-π-π stacking: Contribution of Amide-π and CH-π interactions to Crotonyllysine Binding by the AF9 YEATS Domain.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c06568
Abstract: Lysine crotonylation (Kcr) is a histone post-translational modification that is implicated in numerous epigenetic pathways and diseases. Recognition of Kcr by YEATS domains has been proposed to occur through intermolecular amide-π and alkene-π interactions, but… read more here.
Keywords: yeats domain; af9; af9 yeats; contribution amide ... See more keywords
Structure and energetics of ligand-fluorine interactions with galectin-3 backbone and side-chain amides - insight into solvation effects and multipolar interactions.
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.2210/pdb6qlo/pdb
Abstract: Multipolar fluorine–amide interactions with backbone and side-chain amides have been described as important for protein–ligand interactions and have been used to improve the potency of synthetic inhibitors. In this study, fluorine interactions within a well-defined… read more here.
Keywords: chain; amide interactions; chain amides; backbone side ... See more keywords