[Systemic effects of amide-linked local anesthetics : Old drugs, new magic bullets?]
Sign Up to like & getrecommendations! Published in 2018 at "Der Anaesthesist"
DOI: 10.1007/s00101-018-0453-2
Abstract: Besides the well-known analgesic effects of amide-linked local anesthetics exerted via the inhibition of the voltage-gated sodium channel, these substances also possess a certain number of properties, which bear the potential to positively influence the outcome… read more here.
Keywords: systemic effects; amide linked; linked local; local anesthetics ... See more keywords
Design, synthesis, anticancer and antioxidant activities of amide linked 1,4-disubstituted 1,2,3-triazoles
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.129255
Abstract: Abstract To explore anticancer and antioxidant agents with improved potency, we synthesized a series of amide linked 1,4-disubstituted 1,2,3-triazoles through click chemistry approach. The structure of synthesized triazoles were characterized by- FTIR, 1H NMR, 13C… read more here.
Keywords: activity; disubstituted triazoles; linked disubstituted; amide linked ... See more keywords
Polyamide Covalent Organic Framework Membranes for Molecular Sieving.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c07753
Abstract: Polyamide is an important class of membrane materials for separation technology. The polyamide membranes currently used are amorphous, and thus, their pore structures are disordered, which inevitably decreases their performance in separation. Herein, we report… read more here.
Keywords: polyamide covalent; framework membranes; organic framework; amide linked ... See more keywords
Optimization of Automated Synthesis of Amide-Linked RNA
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DOI: 10.1021/acsomega.2c02742
Abstract: The recent FDA approval of several antisense and siRNA drugs illustrates the utility of nucleic acid chemical modifications, but numerous challenges remain for generalized nucleic acid therapeutics, urging the exploration of new modification strategies. Replacing… read more here.
Keywords: synthesis; nucleic acid; amide linked; linked rna ... See more keywords
Synthesis and characterization of amide linked triazolyl glycolipids as molecular hydrogelators and organogelators
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DOI: 10.1039/c7ra06228a
Abstract: Carbohydrate based small molecular gelators are important classes of compounds which can form useful soft materials with many practical applications. Although many different types of effective gelators have been reported, the rational design of a… read more here.
Keywords: linked triazolyl; molecular hydrogelators; amide linked; molecular gelators ... See more keywords
Structure-guided approach on the role of substitution on amide-linked bipyrazoles and its effect on their anti-inflammatory activity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2109025
Abstract: Abstract A structure-guided modelling approach using COX-2 as a template was used to investigate the effect of replacing the chloro atom located at the chlorophenyl ring of amide-linked bipyrazole moieties, aiming at attaining better anti-inflammatory… read more here.
Keywords: effect; anti inflammatory; inflammatory activity; amide linked ... See more keywords