NDTP Mediated Direct Rapid Amide and Peptide Synthesis without Epimerization.
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DOI: 10.1021/acs.orglett.1c04258
Abstract: Herein, we explored an unprecedented mild, nonirritating, conveniently available, and recyclable coupling reagent NDTP, which could activate the carboxylic acids via acyl thiocyanide and enable the rapid amide and peptide synthesis at very mild conditions.… read more here.
Keywords: rapid amide; mediated direct; amide peptide; ndtp mediated ... See more keywords
Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d3sc00198a
Abstract: Technology for generating especially important amide and peptide bonds from carboxylic acids and amines that avoids traditional coupling reagents is described. The 1-pot processes developed rely on thioester formation, neat, using a simple dithiocarbamate, and… read more here.
Keywords: amide peptide; coupling reagents; peptide bonds; bonds carboxylic ... See more keywords