Discovery of a Series of 5-Amide-1H-pyrazole-3-carboxyl Derivatives as Potent P2Y14R Antagonists with Anti-Inflammatory Characters.
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DOI: 10.1021/acs.jmedchem.2c01632
Abstract: UDPG/P2Y14R signaling pathway has been considered as a potential therapeutic target for innate immune system diseases. Based on the scaffold hopping strategy, a series of pyrazole analogues were designed and synthesized as novel P2Y14R antagonists… read more here.
Keywords: p2y14r antagonists; discovery series; series amide; anti inflammatory ... See more keywords