Total Synthesis of an Epothilone Analogue based on the Amide‒Triazole Bioisosterism.
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DOI: 10.1002/cplu.202400413
Abstract: Epothilones are 16-membered macrolides that can act as microtubule-targeting agents to tackle cancer. Many synthetic analogues have been investigated for their activity, yet often based on macrolide structures. A notable exception is Ixabepilone, an azalide… read more here.
Keywords: total synthesis; amide triazole; epothilone; triazole bioisosterism ... See more keywords
A photo-responsive poly(amide-triazole) physical organogel bearing azobenzene residues in the main chain.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc05096a
Abstract: The synthesis of a click poly(amide-triazole) bearing multiple azobenzene units along the main chain was reported. The polymer was found to form strong physical polymer organogels. This structural design facilitates a much more efficient photomechanical… read more here.
Keywords: main chain; poly amide; photo responsive; amide triazole ... See more keywords