Asymmetric Radical Cyclopropanation of α,β-Unsaturated Amides with α-Boryl and α-Silyl Dibromomethanes via Cr(II)-Based Metalloradical Catalysis.
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DOI: 10.1021/jacs.4c13269
Abstract: Transition-metal-catalyzed asymmetric carbene-transfer reactions represent a powerful strategy for synthesizing chiral cyclopropanes. However, current methods predominantly rely on stabilized carbene-bearing α-π-conjugated groups, restricting access to less stabilized carbenes, such as α-silyl and α-boryl carbenes. Herein,… read more here.
Keywords: boryl silyl; unsaturated amides; amides boryl; cyclopropanation unsaturated ... See more keywords