Cobalt-Catalyzed Direct C-H Thiolation of Aromatic Amides with Disulfides: Application to the Synthesis of Quetiapine.
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DOI: 10.1021/acs.orglett.8b02812
Abstract: A direct C(sp2)-H thiolation of aromatic amides with disulfides was developed. The coupling reaction proceeds between the thioether radical and cobaltacycle intermediate. This method exhibits a relatively broad substrate scope and high functional group compatibility.… read more here.
Keywords: amides disulfides; aromatic amides; cobalt catalyzed; catalyzed direct ... See more keywords