Further studies on the application of vinylogous amides and β-halovinylaldehydes to the regiospecific synthesis of unsymmetrical, polyfunctionalized 2,3,4- and 1,2,3,4- substituted pyrroles.
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DOI: 10.1016/j.tet.2018.04.017
Abstract: Highly functionalized pyrroles with appropriate regiochemical functionality represent an important class of marine natural products and potential drug candidates. We describe herein a detailed study of the reaction of α-aminoacid esters with vinylogous amides and… read more here.
Keywords: amides halovinylaldehydes; regiospecific synthesis; substituted pyrroles; vinylogous amides ... See more keywords