Monoselective N-Methylation of Amides, Indoles, and Related Structures Using Quaternary Ammonium Salts as Solid Methylating Agents
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DOI: 10.1021/acs.orglett.2c02766
Abstract: We herein report the use of phenyl trimethylammonium iodide (PhMe3NI) as a safe, nontoxic, and easy-to-handle reagent for an absolutely monoselective N-methylation of amides and related compounds as well as for the N-methylation of indoles.… read more here.
Keywords: methylation; monoselective methylation; methylation amides; indoles related ... See more keywords