Catalytic Reductive Functionalization of Tertiary Amides using Vaska’s Complex: Synthesis of Complex Tertiary Amine Building Blocks and Natural Products
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DOI: 10.1021/acscatal.0c02377
Abstract: The tertiary amide is a ubiquitous functional group and plays an irreplaceable role in medicinal chemistry. Its robust nature has meant—in the past—that selective manipulation of this motif remaine... read more here.
Keywords: using vaska; reductive functionalization; amides using; functionalization tertiary ... See more keywords
Pd/Ni catalyzed selective N–H/C–H methylation of amides by using peroxides as the methylating reagents via a radical process
Sign Up to like & getrecommendations! Published in 2017 at "Organic chemistry frontiers"
DOI: 10.1039/c7qo00625j
Abstract: A palladium/nickel catalyzed selective N–H/C–H methylation of amides by using peroxides is described, providing N-methylation products and C-methylation products in moderate to good yields. In this procedure, peroxides play a dual role, serving as both… read more here.
Keywords: methylation; catalyzed selective; using peroxides; methylation amides ... See more keywords