Construction of N-Boc monofluoromethyl aryl sulfones via Mannich reaction of α-amido sulfones with trifluoromethyl α-fluorinated arylsulfonyl gem-diols
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2020.109537
Abstract: Abstract A mild and efficient nucleophilic monofluoromethylation of α-amido sulfones with trifluoromethyl α-fluorinated arylsulfonyl gem-diols as new building blocks has been developed, which affords N-Boc monofluoromethyl aryl sulfones in good yields with appropriate 5:1 diastereomeric… read more here.
Keywords: fluorinated arylsulfonyl; amido sulfones; sulfones trifluoromethyl; arylsulfonyl gem ... See more keywords
K2S2O8-Activated Friedel–Crafts Type Alkylation of Indoles with α-Amido Sulfones
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DOI: 10.1055/s-0036-1589073
Abstract: A K 2 S 2 O 8 -activated regioselective alkylation of α-amido sulfones at the C-3 position of indoles is reported. The protocol developed herein provides an alternative new strategy to the previous approach by… read more here.
Keywords: alkylation indoles; amido sulfones; crafts type; alkylation ... See more keywords
Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones
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DOI: 10.3390/molecules27123763
Abstract: A convenient procedure of synthesis of N-carbamoyl-protected propargylic amines substituted with a cyclopropyl group from α-amido sulfones and cyclopropylacetylene is described. The reaction is catalyzed by a chiral BINOL-type zinc complex and provides the corresponding… read more here.
Keywords: cyclopropylalkynylation aldimines; catalytic enantioselective; generated situ; amido sulfones ... See more keywords