Human mitochondrial amidoxime reducing component (mARC): An electrochemical method for identifying new substrates and inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Electrochemistry Communications"
DOI: 10.1016/j.elecom.2017.10.003
Abstract: Abstract As recently as 2006 the mitochondrial amidoxime reducing component (mARC) was identified as the fourth and last Mo enzyme present in humans. Its physiological role remains unknown. mARC is capable of reducing a variety… read more here.
Keywords: mitochondrial amidoxime; substrates inhibitors; amidoxime reducing; reducing component ... See more keywords
A novel mitochondrial amidoxime reducing component 2 is a favorable indicator of cancer and suppresses the progression of hepatocellular carcinoma by regulating the expression of p27
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-01417-6
Abstract: Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer-related mortality in the United States. Exploring the mechanism of HCC and identifying ideal targets is critical. In the present study, we demonstrated metabolism dysfunction might… read more here.
Keywords: hepatocellular carcinoma; mitochondrial amidoxime; hcc; amidoxime reducing ... See more keywords
The Involvement of the Mitochondrial Amidoxime Reducing Component (mARC) in the Reductive Metabolism of Hydroxamic Acids
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.118.082453
Abstract: The mitochondrial amidoxime reducing component is a recently discovered molybdenum enzyme in mammals which, in concert with the electron transport proteins cytochrome b5 and NADH cytochrome b5 reductase, catalyzes the reduction of N-oxygenated structures. This… read more here.
Keywords: mitochondrial amidoxime; amidoxime reducing; system; metabolism ... See more keywords
Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.121.000805
Abstract: Mitochondrial amidoxime-reducing component (mARC) enzymes are molybdenum-containing proteins that metabolize a number of endobiotics and xenobiotics. The interindividual variability and differential tissue abundance of mARC1 and mARC2 were quantified using targeted proteomics in three types… read more here.
Keywords: mitochondrial amidoxime; reducing component; tissue; abundance ... See more keywords