Allosteric modulation of G protein‐coupled receptors by amiloride and its derivatives. Perspectives for drug discovery?
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21633
Abstract: The function of G protein‐coupled receptors (GPCRs) can be modulated by compounds that bind to other sites than the endogenous orthosteric binding site, so‐called allosteric sites. Structure elucidation of a number of GPCRs has revealed… read more here.
Keywords: amiloride analogs; receptors amiloride; protein coupled; coupled receptors ... See more keywords
Novel Amiloride Derivatives That Inhibit Bacterial Motility across Multiple Strains and Stator Types
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bacteriology"
DOI: 10.1128/jb.00367-21
Abstract: Here, we characterized two novel amiloride derivatives in the search for antimicrobial compounds that target bacterial motility. Our two compounds were shown to inhibit flagellar motility at 10 μM across multiple strains: from nonpathogenic Escherichia coli… read more here.
Keywords: bacterial motility; coli; rotation; motility ... See more keywords