Enantioselective α-Amination of Acyclic 1,3-Dicarbonyls Catalyzed by N-Heterocyclic Carbene.
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DOI: 10.1021/acs.orglett.9b04232
Abstract: Herein, we describe a method for the catalytic enantioselective α-amination of α-substituted acyclic 1,3-ketoamides and 1,3-amidoesters that affords the products possessing N-substituted quaternary stereocenters with a chiral N-heterocyclic carbene (NHC). The reaction is based on… read more here.
Keywords: amination acyclic; acyclic dicarbonyls; enantioselective amination; heterocyclic carbene ... See more keywords