A Mechanistic Study of the Cobalt(I)-Catalyzed Amination of Aryl Halides: Effects of Metal and Ligand.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c02385
Abstract: Transition-metal-catalyzed amination of aryl halides is a useful approach for the synthesis of medicinal compounds, organic functional materials, and agrochemical compounds. A systematic DFT study has been performed to investigate the mechanism of the Co(I)-catalyzed… read more here.
Keywords: aryl halides; catalyzed amination; amination; amination aryl ... See more keywords
Palladium-Catalyzed Amination of Aryl Sulfoxides.
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DOI: 10.1021/acs.orglett.8b00060
Abstract: Amination of diaryl sulfoxides with anilines and alkylamines has been accomplished under palladium/N-heterocyclic carbene (NHC) catalysis. Owing to its electron deficiency, the leaving arenesulfenate anion would be smoothly released from the palladium center to result… read more here.
Keywords: amination aryl; palladium catalyzed; catalyzed amination; amination ... See more keywords
Amination of Aryl Boronic Acids with Alkylnitrites: A Convenient Complement to Cu-Promoted Reductive Amination.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03961
Abstract: Copper-catalyzed amination of aryl boronic acids with alkylnitrites leading to symmetrical diarylamines with a practical 50-80% yield was elaborated. Two C(sp2)-N bonds are formed in the one-pot process under mild conditions. This new approach to… read more here.
Keywords: acids alkylnitrites; boronic acids; reductive amination; amination ... See more keywords
A Fast Track to Indoles and Annulated Indoles through ortho- vs ipso-Amination of Aryl Halides.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b04202
Abstract: A complementary site selective ortho- vs ipso-amination of aryl halides using non-electrophilic amine sources for construction of indole scaffolds is reported. A palladium-catalyzed alkyne insertion/C-H activation/palladacycle amination via merger of three easily diversified components including… read more here.
Keywords: ipso amination; amination; aryl halides; amination aryl ... See more keywords
Room-Temperature Cu-Catalyzed Amination of Aryl Bromides Enabled by DFT-Guided Ligand Design.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c00500
Abstract: Ullmann-type C-N coupling reactions represent an important alternative to well-established Pd-catalyzed approaches due to the differing reactivity and the lower cost of Cu. While the design of anionic Cu ligands, particularly those by Ma, has… read more here.
Keywords: aryl; catalyzed amination; design; amination aryl ... See more keywords
Nickel-Catalyzed Amination of α-Aryl Methyl Ethers
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DOI: 10.1055/s-0039-1690718
Abstract: α-Aryl amines are prevalent in pharmaceutically active compounds and natural products. Herein, we describe a Ni-catalyzed protocol for their synthesis from readily available α-aryl ethers. While α-aryl ethers have been used as electrophiles in Ni-catalyzed… read more here.
Keywords: aryl methyl; methyl ethers; catalyzed amination; amination aryl ... See more keywords