Pd-catalyzed stereoselective tandem ring-opening amination/cyclization of vinyl γ-lactones: access to caprolactam diversity†
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DOI: 10.1039/d0sc03647a
Abstract: A stereoselective amination/cyclization cascade process has been developed that allows for the preparation of a series of unsaturated and substituted caprolactam derivatives in good yields. This conceptually novel protocol takes advantage of the easy access… read more here.
Keywords: ring opening; amination; amination cyclization; vinyl lactones ... See more keywords
An HFIP-assisted, cobalt-catalyzed three-component electrophilic C-H amination/cyclization/directing group removal cascade to naphtho[1,2-d]imidazoles.
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DOI: 10.1039/d3cc00749a
Abstract: A concise and efficient method has been developed herein for the synthesis of valuable naphtho[1,2-d]imidazole derivatives. It involves an earth-abundant cobalt-catalyzed electrophilic ortho C-H amination/cyclization/directing group removal cascade with O-benzoloxyamines using paraformaldehyde as a one… read more here.
Keywords: cobalt catalyzed; group removal; amination cyclization; group ... See more keywords
Synthesis of Functionalized Azepines via Cu(I)-Catalyzed Tandem Amination/Cyclization Reaction of Fluorinated Allenynes
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DOI: 10.3390/molecules27165195
Abstract: An efficient method for the selective preparation of trifluoromethyl-substituted azepin-2-carboxylates and their phosphorous analogues has been developed via Cu(I)-catalyzed tandem amination/cyclization reaction of functionalized allenynes with primary and secondary amines. read more here.
Keywords: catalyzed tandem; tandem amination; cyclization reaction; via catalyzed ... See more keywords