C2-Selective, Functional-Group-Divergent Amination of Pyrimidines by Enthalpy-Controlled Nucleophilic Functionalization.
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DOI: 10.1021/jacs.1c13373
Abstract: Synthesis of heteroaryl amines has been an important topic in organic chemistry because of their importance in small-molecule discovery. In particular, 2-aminopyrimidines represent a highly privileged structural motif that is prevalent in bioactive molecules, but… read more here.
Keywords: amination pyrimidines; functionalization; selective functional; group divergent ... See more keywords