Electrochemical Amidation: Benzoyl Hydrazine/Carbazate and Amine as Coupling Partners.
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DOI: 10.1021/acs.orglett.2c02626
Abstract: An electrochemical amidation of benzoyl hydrazine/carbazate and primary/secondary amine as coupling partners via concomitant cleavage and formation of C(sp2)-N bonds has been achieved. This methodology proceeds under metal-free and exogenous oxidant-free conditions producing N2 and… read more here.
Keywords: electrochemical amidation; amine coupling; amidation benzoyl; benzoyl hydrazine ... See more keywords
The Asymmetric A3(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines
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DOI: 10.3390/molecules24071216
Abstract: The recent developments in asymmetric A3 (aldehyde–alkyne–amine) coupling has been summarized in this review. Several interesting modifications of the ligands enabled the highly enantioselective synthesis of chiral propargylamines, which are further used in the construction… read more here.
Keywords: aldehyde alkyne; asymmetric aldehyde; highly enantioselective; alkyne amine ... See more keywords
Phosphonodithioester–Amine Coupling as a Key Reaction Step for the Design of Cationic Amphiphiles Used for Gene Delivery
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DOI: 10.3390/molecules26247507
Abstract: A convergent synthesis of cationic amphiphilic compounds is reported here with the use of the phosphonodithioester–amine coupling (PAC) reaction. This versatile reaction occurs at room temperature without any catalyst, allowing binding of the lipid moiety… read more here.
Keywords: phosphonodithioester amine; delivery; amine coupling; cationic amphiphiles ... See more keywords