Mechanistic Insight into the Catalytic Promiscuity of Amine Dehydrogenases: Asymmetric Synthesis of Secondary and Primary Amines
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DOI: 10.1002/cbic.201800626
Abstract: Biocatalytic asymmetric amination of ketones, by using amine dehydrogenases (AmDHs) or transaminases, is an efficient method for the synthesis of α‐chiral primary amines. A major challenge is to extend amination to the synthesis of secondary… read more here.
Keywords: primary amines; synthesis secondary; nad dependent; secondary amines ... See more keywords
Understanding and Overcoming the Limitations of Bacillus badius and Caldalkalibacillus thermarum Amine Dehydrogenases for Biocatalytic Reductive Amination
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DOI: 10.1021/acscatal.7b00516
Abstract: The direct asymmetric reductive amination of ketones using ammonia as the sole amino donor is a growing field of research in both chemocatalysis and biocatalysis. Recent research has focused on the enzyme engineering of amino… read more here.
Keywords: bacillus badius; caldalkalibacillus thermarum; amine dehydrogenases; reductive amination ... See more keywords