Rational Design and Synthesis of 1‐(Arylideneamino)‐4‐aryl‐1H‐imidazole‐2‐amine Derivatives as Antiplatelet Agents
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700123
Abstract: Based on previous studies indicating the pharmacophoric role of a hydrazone group and azole rings for antiplatelet aggregation activity, a few series of compounds with both hydrazone and an azole (imidazole) ring in their structures… read more here.
Keywords: amine derivatives; aggregation; aryl imidazole; imidazole amine ... See more keywords
Effects of fatty acid-ethanol amine (FA-EA) derivatives on lipid accumulation and inflammation.
Sign Up to like & getrecommendations! Published in 2023 at "Lipids"
DOI: 10.1002/lipd.12368
Abstract: This study aimed to investigate the effect of fatty acid-ethanol amine (FA-EA) derivatives (L1-L10) on the mitigation of intracellular lipid accumulation and downregulation of pro-inflammatory cytokines in vitro. First, the series of FA-EA derivatives were… read more here.
Keywords: acid ethanol; accumulation; lipid accumulation; amine derivatives ... See more keywords
Molecular docking and MD simulation studies of 4-thiazol-N-(pyridin-2-yl)pyrimidin-2-amine derivatives as novel inhibitors targeted to CDK2/4/6
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-024-05818-y
Abstract: Nowadays, cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have been approved for treating metastatic breast cancer and have achieved inspiring curative effects. But some discoveries have indicated that CDK 4/6 are not the requisite factors in some… read more here.
Keywords: molecular docking; cdk2 inhibitors; cdk2; amine derivatives ... See more keywords
Synthesis and anticholinesterase activity of novel non-hepatotoxic naphthyridine-11-amine derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Diversity"
DOI: 10.1007/s11030-018-9897-1
Abstract: In the present study, 14 novel naphthyridine-11-amine derivatives were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 12-(4-Fluorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1, 8]naphthyridin-11-amine (4a) was found to be the most potent AChE inhibitor with… read more here.
Keywords: amine; amine derivatives; synthesis anticholinesterase; anticholinesterase activity ... See more keywords
Discovery of Novel (+)-Nootkatone-Based Amine Derivatives as Potential Insecticide Candidates.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c02697
Abstract: To discover novel natural product-based insecticides, a series of (+)-nootkatone-based amine derivatives 3a-t were prepared and evaluated for their insecticidal activities against Mythimna separata Walker, Myzus persicae Sulzer, and Plutella xylostella Linnaeus. Insecticidal assays showed… read more here.
Keywords: based amine; amine derivatives; xylostella; nootkatone ... See more keywords
Synergistic Enhancing of Biological Activity and Natural Light Self-Degradation of Organic-Inorganic Hybrid Nano-organometallic Pesticide-Fused Phenylpyrazole Amine Derivatives with Hollow Box TiO2 by One-pot Microwave Synthesis.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c11589
Abstract: Nano-TiO2 as an antimicrobial inorganic material, can stimulate cells to produce reactive oxygen species and exhibit effective biochemical properties; however, phenylpyrazole derivatives, as organic pesticides, are widely used in agriculture and food. To find novel… read more here.
Keywords: pesticide; phenylpyrazole amine; nano organometallic; amine derivatives ... See more keywords
N-(Pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine Derivatives as Selective Janus Kinase 2 Inhibitors for the Treatment of Myeloproliferative Neoplasms.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01488
Abstract: In this study, we described a series of N-(pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine derivatives as selective JAK2 (Janus kinase 2) inhibitors. Systematic exploration of the structure-activity relationship though cyclization modification based on previously reported compound 18e led to the… read more here.
Keywords: amine derivatives; tetrahydroisoquinolin amine; kinase; derivatives selective ... See more keywords
Selective palladium(ii)-mediated oxidation of homoallylic N-tert-butanesulfinyl amine derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc00826k
Abstract: The palladium(ii)-catalyzed oxidation of homoallylic amine derivatives resulting from the allylation of N-tert-butanesulfinyl imines with allyl bromide led to the formation of the corresponding terminal allylic acetates in a regioselective fashion in moderate yields. In… read more here.
Keywords: amine derivatives; oxidation; oxidation homoallylic; tert butanesulfinyl ... See more keywords
Investigating chronic myeloid leukemia therapeutics: AI-optimized design and synthesis of 4-methylthiazole-2-amine derivatives with translocation control activity
Sign Up to like & getrecommendations! Published in 2025 at "RSC Advances"
DOI: 10.1039/d5ra07232h
Abstract: A series of 4-methylthiazole-2-amine derivatives (3a–3f, 6g–j and 7) were prepared via a Hantzsch-type multicomponent reaction and characterized by FT-IR, 1H-NMR and 13C-NMR spectroscopy techniques. The cytotoxic effects of the synthesized products on the chronic… read more here.
Keywords: chronic myeloid; methylthiazole amine; amine derivatives; myeloid leukemia ... See more keywords
5-(3,5-Dinitrophenyl)-1,3,4-oxadiazol-2-amine derivatives, their precursors, and analogues: Synthesis and evaluation of novel highly potent antitubercular agent
Sign Up to like & getrecommendations! Published in 2025 at "PLOS One"
DOI: 10.1371/journal.pone.0324608
Abstract: Drug resistance is a growing problem for many pathogens, including mycobacteria. Small heterocyclic molecules are among the leading scaffolds for developing potential antimycobacterial agents. Therefore, based on the molecular hybridization approach, we have prepared an… read more here.
Keywords: amine derivatives; oxadiazol amine; dinitrophenyl oxadiazol; derivatives precursors ... See more keywords
Synthesis and In-silico Studies of 4-Phenyl thiazol-2-amine Derivatives as Putative Anti-Breast Cancer Agents.
Sign Up to like & getrecommendations! Published in 2023 at "Current computer-aided drug design"
DOI: 10.2174/1573409919666230321145543
Abstract: BACKGROUND Breast cancer (BC) is the second-leading cause of cancer-related fatalities in women after lung cancer worldwide. The development of BC is significantly influenced by estrogen receptors (ERs). The problem with current cancer treatments is… read more here.
Keywords: amine derivatives; breast cancer; cancer; synthesis silico ... See more keywords