Rational Design and Synthesis of 1‐(Arylideneamino)‐4‐aryl‐1H‐imidazole‐2‐amine Derivatives as Antiplatelet Agents
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DOI: 10.1002/cmdc.201700123
Abstract: Based on previous studies indicating the pharmacophoric role of a hydrazone group and azole rings for antiplatelet aggregation activity, a few series of compounds with both hydrazone and an azole (imidazole) ring in their structures… read more here.
Keywords: amine derivatives; aggregation; aryl imidazole; imidazole amine ... See more keywords
Effects of fatty acid-ethanol amine (FA-EA) derivatives on lipid accumulation and inflammation.
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DOI: 10.1002/lipd.12368
Abstract: This study aimed to investigate the effect of fatty acid-ethanol amine (FA-EA) derivatives (L1-L10) on the mitigation of intracellular lipid accumulation and downregulation of pro-inflammatory cytokines in vitro. First, the series of FA-EA derivatives were… read more here.
Keywords: acid ethanol; accumulation; lipid accumulation; amine derivatives ... See more keywords
Synthesis and anticholinesterase activity of novel non-hepatotoxic naphthyridine-11-amine derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Diversity"
DOI: 10.1007/s11030-018-9897-1
Abstract: In the present study, 14 novel naphthyridine-11-amine derivatives were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 12-(4-Fluorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1, 8]naphthyridin-11-amine (4a) was found to be the most potent AChE inhibitor with… read more here.
Keywords: amine; amine derivatives; synthesis anticholinesterase; anticholinesterase activity ... See more keywords
N-(Pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine Derivatives as Selective Janus Kinase 2 Inhibitors for the Treatment of Myeloproliferative Neoplasms.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01488
Abstract: In this study, we described a series of N-(pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine derivatives as selective JAK2 (Janus kinase 2) inhibitors. Systematic exploration of the structure-activity relationship though cyclization modification based on previously reported compound 18e led to the… read more here.
Keywords: amine derivatives; tetrahydroisoquinolin amine; kinase; derivatives selective ... See more keywords
Selective palladium(ii)-mediated oxidation of homoallylic N-tert-butanesulfinyl amine derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc00826k
Abstract: The palladium(ii)-catalyzed oxidation of homoallylic amine derivatives resulting from the allylation of N-tert-butanesulfinyl imines with allyl bromide led to the formation of the corresponding terminal allylic acetates in a regioselective fashion in moderate yields. In… read more here.
Keywords: amine derivatives; oxidation; oxidation homoallylic; tert butanesulfinyl ... See more keywords
Synthesis and In-silico Studies of 4-Phenyl thiazol-2-amine Derivatives as Putative Anti-Breast Cancer Agents.
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DOI: 10.2174/1573409919666230321145543
Abstract: BACKGROUND Breast cancer (BC) is the second-leading cause of cancer-related fatalities in women after lung cancer worldwide. The development of BC is significantly influenced by estrogen receptors (ERs). The problem with current cancer treatments is… read more here.
Keywords: amine derivatives; breast cancer; cancer; synthesis silico ... See more keywords
Synthesis and Biological Evaluation of Novel Pyrimidine Amine Derivatives Bearing Bicyclic Monoterpene Moieties
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DOI: 10.3390/molecules27228104
Abstract: A series of novel pinanyl pyrimidine amine derivatives (1e~1n) and camphoryl pyrimidine amine derivatives (2b~2f) bearing bicyclic monoterpene moieties were designed and synthesized from natural and renewable nopinone and camphor. All chemical structures of target… read more here.
Keywords: bearing bicyclic; amine derivatives; pyrimidine amine; bicyclic monoterpene ... See more keywords
Exploring Kinase Inhibition Properties of 9H-pyrimido[5,4-b]- and [4,5-b]indol-4-amine Derivatives
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DOI: 10.3390/ph13050089
Abstract: We previously highlighted the interest in 6,5,6-fused tricyclic analogues of 4-aminoquinazolines as kinase inhibitors in the micromolar to the nanomolar range of IC50 values. For the generation of chemical libraries, the formamide-mediated cyclization of the… read more here.
Keywords: amine derivatives; kinase inhibition; pyrimido indol; indol amine ... See more keywords