Boosting ionizable lipid nanoparticle-mediated in vivo mRNA delivery through optimization of lipid amine-head groups.
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DOI: 10.1039/d1bm00866h
Abstract: In vitro transcribed messenger RNA (IVT-mRNA) holds great promise for the development of novel therapeutics, such as immunotherapy and vaccination. However, the main obstacle towards clinical translation is the lack of effective delivery systems. Herein,… read more here.
Keywords: head; ilnp; delivery; amine head ... See more keywords