Snap-Trapping Strategy for Amine-Specific Bioconjugation with Pyridotriazole Carbaldehydes.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c15886
Abstract: While thiol-targeting methods have long defined the gold standard in bioconjugation, selective and clean modification of more abundant but intrinsically less nucleophilic amine groups remains a challenge. Methods that match the reactivity and precision of… read more here.
Keywords: amine; snap trapping; amine specific; trapping strategy ... See more keywords
Alkynone β-trifluoroborates: A new class of amine-specific biocompatible click reagents
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adg4924
Abstract: Amine-targeting reactions that work under biocompatible conditions or in water are green processes that are extremely useful for the synthesis of functional materials and biotherapeutics. Unfortunately, despite the usefulness of this reaction, there are very… read more here.
Keywords: click; amine specific; alkynone trifluoroborates; new class ... See more keywords