Chemoselective Thioacylation of Amines Enabled by Synergistic Defluorinative Coupling.
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DOI: 10.1021/acs.orglett.4c02237
Abstract: A mild and chemoselective method for the thioacylation of amines, including amino acids and peptides, using gem-difluoroalkenes and sulfide, is reported. The distinguishing of the different nucleophilic sites (S-site and diverse N-sites) by the chemoselective… read more here.
Keywords: chemoselective thioacylation; synergistic defluorinative; thioacylation amines; amines enabled ... See more keywords