Stereoselective Aminoiodination of Activated Alkynes with Organoiodine(III) Reagents and Amines via Multiple-Site Functionalization: Access to Iodinated Enamines and N -Aryl Indoles
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201801725
Abstract: A stereoselective aminoiodination of activated alkynes with PhI(OAc)2 and amines via multiple-site functionalization to afford (Z)diethyl 2-(diphenylamino)-3-iodomaleate derivatives with superior yields has been described. The key feature of this reaction is the incorporation of iodide… read more here.
Keywords: activated alkynes; stereoselective aminoiodination; amines via; via multiple ... See more keywords
Chiral piperidines from acyclic amines via enantioselective, radical-mediated δ C-H cyanation.
Sign Up to like & getrecommendations! Published in 2019 at "Chem"
DOI: 10.1016/j.chempr.2019.09.010
Abstract: Piperidines are the most prevalent heterocycle found in medicines. Yet, while they are often chiral, there remain no robust methods for their asymmetric syntheses. To solve this challenge, we have interrupted the century-old Hofmann-Löffler-Freytag (HLF)… read more here.
Keywords: piperidines acyclic; chiral piperidines; amines via; cyanation ... See more keywords
Ambient-Temperature Synthesis of Primary Amines via Reductive Amination of Carbonyl Compounds
Sign Up to like & getrecommendations! Published in 2020 at "ACS Catalysis"
DOI: 10.1021/acscatal.0c01872
Abstract: Efficient synthesis of primary amines via low-temperature reductive amination of carbonyl compounds using NH3 and H2 as the nitrogen and hydrogen resources is highly desired and challenging in the ... read more here.
Keywords: primary amines; amines via; synthesis primary; carbonyl compounds ... See more keywords
Cross-Coupling of Amines via Photocatalytic Denitrogenation of In Situ Generated Diazenes.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c03634
Abstract: A method for C(sp3)-C(sp3) cross-coupling of amines is described. Primary amines are converted to 1,2-dialkyldiazenes by treatment with O-nosylhydroxylamines in the presence of atmospheric oxygen. Denitrogenation of the diazenes with an iridium photocatalyst then forges… read more here.
Keywords: via photocatalytic; coupling amines; cross coupling; denitrogenation ... See more keywords
C-H Functionalization of Amines via Alkene-Derived Nucleophiles through Cooperative Action of Chiral and Achiral Lewis Acid Catalysts: Applications in Enantioselective Synthesis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b06699
Abstract: Catalytic transformations of α-amino C-H bonds to afford valuable enantiomerically enriched α-substituted amines, entities that are prevalent in pharmaceuticals and bioactive natural products, have been developed. Typically, such processes are carried out under oxidative conditions… read more here.
Keywords: derived nucleophiles; alkene derived; functionalization amines; amines via ... See more keywords
Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc01670h
Abstract: A series of new Mg(ii) amides featuring a bulky β-diketiminate backstop ligand, has been synthesised. These complexes are demonstrated to be excellent sources of nucleophilic amides that can participate in rapid C-F activation of several… read more here.
Keywords: arylation amines; amines via; mediated arylation; activation ... See more keywords
Diversity-oriented synthesis of fluoroalkylated amines via the palladium-catalyzed divergent fluoroalkylamination of 1,3-dienes.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00983h
Abstract: Herein, we reported the first versatile and expeditious protocol for the diversity-oriented synthesis (DOS) of fluoroalkylated amines via the photoinduced palladium-catalyzed cross coupling of 1,3-dienes, amines and fluoroalkyl iodides, which features excellent 3,4- and 1,4-selectivity… read more here.
Keywords: oriented synthesis; fluoroalkylated amines; palladium catalyzed; diversity oriented ... See more keywords
Sequential hydrogenation of nitroaromatics to alicyclic amines via highly-dispersed Ru–Pd nanoparticles anchored on air-exfoliated C3N4 nanosheets
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra07612h
Abstract: Developing efficient and green catalytic systems is highly desired in the syntheses of alicyclic amines via hydrogenation of nitroaromatics. Herein, we developed Ru–Pd dual active site catalysts in which Ru and Pd species were anchored… read more here.
Keywords: amines via; highly dispersed; hydrogenation; hydrogenation nitroaromatics ... See more keywords