Mutational analyses identify a single amino acid critical for colour tuning in proteorhodopsins
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14297
Abstract: Microbial rhodopsins are light‐activated proteins that contain seven transmembrane alpha‐helices. Spectral tuning in microbial rhodopsins is a useful optogenetic tool. In this study, we report a new site that controls spectral tuning. In the proteorhodopsins… read more here.
Keywords: single amino; amino acid; spectral tuning; tuning proteorhodopsins ... See more keywords
Ionizable Amino-Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino-Alcohols for Tissue Selective mRNA Delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced materials"
DOI: 10.1002/adma.201801151
Abstract: The utility of messenger RNA (mRNA) as a therapy is gaining a broad interest due to its potential for addressing a wide range of diseases, while effective delivery of mRNA molecules to various tissues still… read more here.
Keywords: amino; delivery; amino polyesters; amino alcohols ... See more keywords
Tuning the Magnetization of Manganese (II) Carbonate by Intracrystalline Amino Acids
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DOI: 10.1002/adma.202201652
Abstract: Incorporation of organic molecules into the lattice of inorganic crystalline hosts is a common phenomenon in biomineralization and is shown to alter various properties of the crystalline host. Taking this phenomenon as a source of… read more here.
Keywords: amino acids; magnetization manganese; manganese carbonate; tuning magnetization ... See more keywords
Capillary and microchip electrophoresis method development for amino acid monitoring during biopharmaceutical cultivation
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202100325
Abstract: The increased use of biopharmaceuticals calls for improved means of bioprocess monitoring. In this work, capillary electrophoresis (CE) and microchip electrophoresis (MCE) methods were developed and applied for the analysis of amino acids (AAs) in… read more here.
Keywords: microchip electrophoresis; cultivation; analysis; amino ... See more keywords
Flexible customization of the self‐assembling abilities of short elastin‐like peptide Fn analogs by substituting N‐terminal amino acids
Sign Up to like & getrecommendations! Published in 2022 at "Biopolymers"
DOI: 10.1002/bip.23521
Abstract: Elastin‐like peptides (ELPs) are thermoresponsive biopolymers inspired by the characteristic repetitive sequences of natural elastin. As ELPs exhibit temperature‐dependent reversible self‐assembly, they are expected to be biocompatible thermoresponsive materials for drug delivery carriers. One of… read more here.
Keywords: self assembling; amino acids; amino; elastin like ... See more keywords
An Aminocaprolactam Racemase from Ochrobactrum anthropi with Promiscuous Amino Acid Ester Racemase Activity
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800265
Abstract: The kinetic resolution of amino acid esters (AAEs) is a useful synthetic strategy for the preparation of single‐enantiomer amino acids. The development of an enzymatic dynamic kinetic resolution (DKR) process for AAEs, which would give… read more here.
Keywords: ester racemase; acid ester; amino; amino acid ... See more keywords
Enzymatic Cascade in Pseudomonas that Produces Pyrazine from α‐Amino Acids
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201900448
Abstract: Pyrazines are widespread chemical compounds that include pheromones and odors. Herein, a novel mechanism used by Pseudomonas fluorescens SBW25 to biosynthesize monocyclic pyrazines is reported. Heterologous expression of the papABC genes that synthesize the natural… read more here.
Keywords: amino; amino acids; produces pyrazine; enzymatic cascade ... See more keywords
Photosensitized Oxidative Dimerization at Tyrosine by a Water‐Soluble 4‐Amino‐1,8‐naphthalimide
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202100193
Abstract: The oxidation of proteins generates reactive amino acid (AA) residue intermediates, leading to protein modification and cross‐linking. Aerobic studies with peptides and photosensitizers allow for the controlled generation of reactive oxygen species (ROS) and reactive… read more here.
Keywords: amino naphthalimide; amino; oxidation; tyrosine ... See more keywords
Scalable and Selective β‐Hydroxy‐α‐Amino Acid Synthesis Catalyzed by Promiscuous l‐Threonine Transaldolase ObiH
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DOI: 10.1002/cbic.202100577
Abstract: Enzymes from secondary metabolic pathways possess broad potential for the selective synthesis of complex bioactive molecules. However, the practical application of these enzymes for organic synthesis is dependent on the development of efficient, economical, operationally… read more here.
Keywords: threonine transaldolase; amino acids; synthesis; hydroxy amino ... See more keywords
Stimulus‐Responsive Amino Acids Behind In Situ Assembled Bioactive Peptide Materials
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DOI: 10.1002/cbic.202200497
Abstract: In situ self‐assembly of peptides into well‐defined nanostructures represents one of versatile strategies for creation of bioactive materials within living cells with great potential in disease diagnosis and treatment. The intimate relationship between amino acid… read more here.
Keywords: amino acids; situ; stimulus responsive; responsive amino ... See more keywords
Expansion of the Substrate Specificity of Porcine Kidney D‐Amino Acid Oxidase for S‐Stereoselective Oxidation of 4‐Cl‐Benzhydrylamine
Sign Up to like & getrecommendations! Published in 2018 at "Chemcatchem"
DOI: 10.1002/cctc.201800614
Abstract: Discovery and development of enzymes for the synthesis of chiral amines have been a hot topic for basic and applied aspects of biocatalysts. Based on our X‐ray crystallographic analyses of porcine kidney D‐amino acid oxidase… read more here.
Keywords: acid oxidase; amino; kidney amino; amino acid ... See more keywords