Mutational analyses identify a single amino acid critical for colour tuning in proteorhodopsins
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14297
Abstract: Microbial rhodopsins are light‐activated proteins that contain seven transmembrane alpha‐helices. Spectral tuning in microbial rhodopsins is a useful optogenetic tool. In this study, we report a new site that controls spectral tuning. In the proteorhodopsins… read more here.
Keywords: single amino; amino acid; spectral tuning; tuning proteorhodopsins ... See more keywords
GCN2 kinase-mediated upregulation of ubiquitin C maintains intracellular glutamine level and tRNAGln (CUG) charging under amino acid starvation.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14628
Abstract: Each tRNA is aminoacylated (charged) with a genetic codon-specific amino acid. It remains unclear what factors are associated with tRNA charging and how tRNA charging is maintained. By using the individual tRNA acylation PCR (i-tRAP)… read more here.
Keywords: glutamine level; acid starvation; cug; amino acid ... See more keywords
Amino‐Acid‐Encoded Supramolecular Photothermal Nanomedicine for Enhanced Cancer Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202200139
Abstract: Photothermal nanomedicine based on self‐assembly of biological components, with excellent biosafety and customized performance, is vital significance for precision cancer therapy. However, the programmable design of photothermal nanomedicine remains extremely challenging due to the vulnerability… read more here.
Keywords: photothermal nanomedicine; cancer therapy; amino acid;
A Metabolic Reprogramming Amino Acid Polymer as an Immunosurveillance Activator and Leukemia Targeting Drug Carrier for T‐Cell Acute Lymphoblastic Leukemia
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DOI: 10.1002/advs.202104134
Abstract: Abstract Compromised immunosurveillance leads to chemotherapy resistance and disease relapse of hematological malignancies. Amino acid metabolism regulates immune responses and cancer; however, a druggable amino acid metabolite to enhance antitumor immunosurveillance and improve leukemia targeting‐therapy… read more here.
Keywords: immunosurveillance; cell; leukemia; metabolic reprogramming ... See more keywords
Gene therapy improves brain white matter in aromatic l‐amino acid decarboxylase deficiency
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DOI: 10.1002/ana.25467
Abstract: Children with aromatic l‐amino acid decarboxylase (AADC) deficiency suffer from severe motor dysfunction. Restoration of dopamine levels in the putamen by gene therapy has led to significant improvement in motor function. This study explored brain… read more here.
Keywords: acid decarboxylase; aromatic amino; amino acid; gene therapy ... See more keywords
Thoughts on the role of endogenous D‐cysteine in neuronal function
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200089
Abstract: is an understudied and underappreciated endogenous amino acid in the brain. Its role in neuronal function has been understudied for years due to the difficulty in detecting it. There is recent work showing that D-cysteine… read more here.
Keywords: role endogenous; role; thoughts role; amino acid ... See more keywords
Effect of amino acid composition of elastin-like polypeptide nanoparticles on nonspecific protein adsorption, macrophage cell viability and phagocytosis.
Sign Up to like & getrecommendations! Published in 2021 at "Biopolymers"
DOI: 10.1002/bip.23468
Abstract: Development of elastin-like polypeptide (ELP) biomaterials is widespread, but information critical for clinical deployment is limited, with biocompatibility studies focused on a narrow cross-section of ELP sequences. Macrophages can impair biomaterial systems by degrading or… read more here.
Keywords: elp nps; amino acid; elp; elastin like ... See more keywords
Modeling the impact of amino acid substitution in a monoclonal antibody on cation exchange chromatography
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27798
Abstract: A vital part of biopharmaceutical research is decision making around which lead candidate should be progressed in early‐phase development. When multiple antibody candidates show similar biological activity, developability aspects are taken into account to ease… read more here.
Keywords: cation exchange; antibody; amino acid; exchange chromatography ... See more keywords
An Aminocaprolactam Racemase from Ochrobactrum anthropi with Promiscuous Amino Acid Ester Racemase Activity
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DOI: 10.1002/cbic.201800265
Abstract: The kinetic resolution of amino acid esters (AAEs) is a useful synthetic strategy for the preparation of single‐enantiomer amino acids. The development of an enzymatic dynamic kinetic resolution (DKR) process for AAEs, which would give… read more here.
Keywords: ester racemase; acid ester; amino; amino acid ... See more keywords
Impact of bPNA Backbone Structural Constraints and Composition on Triplex Hybridization with DNA
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DOI: 10.1002/cbic.202100707
Abstract: We report herein a study on the impact of bifacial peptide nucleic acid (bPNA) amino acid composition and backbone modification on DNA binding. A series of bPNA backbone variants with identical net charge were synthesized… read more here.
Keywords: dna; composition; hybrid stability; bpna backbone ... See more keywords
Principles of Amino‐Acid‐Nucleotide Interactions Revealed by Binding Affinities between Homogeneous Oligopeptides and Single‐Stranded DNA Molecules
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DOI: 10.1002/cbic.202200048
Abstract: We have determined the binding strengths between nucleotides of adenine, thymine, guanine and cytosine in homogeneous single stranded DNAs and homo‐octapeptides consisting of 20 common amino acids. We use a bead‐based fluorescence assay for these… read more here.
Keywords: acid nucleotide; single stranded; dna; principles amino ... See more keywords