Polyamines interfere with protein ubiquitylation and cause depletion of intracellular amino acids: a possible mechanism for cell growth inhibition
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13299
Abstract: Spermidine is a polyamine present in eukaryotes with essential functions in protein synthesis. At high concentrations spermidine and norspermidine inhibit growth by unknown mechanisms. Transcriptomic analysis of the effect of norspermidine on the plant Arabidopsis… read more here.
Keywords: amino acids; protein ubiquitylation; growth inhibition; depletion ... See more keywords
Mechanomorphogenic Films Formed via Interfacial Assembly of Fluorinated Amino Acids
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202104223
Abstract: Nature has evolved several elegant strategies to organize inert building blocks into adaptive supramolecular structures. Favored among these is interfacial self‐assembly, where the unique environment of liquid–liquid junctions provides structural, kinetic, thermodynamic, and chemical properties… read more here.
Keywords: formed via; assembly; amino acids; films formed ... See more keywords
Nature-Inspired Circular-Economy Recycling for Proteins: Proof of Concept.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202104581
Abstract: The billion tons of synthetic-polymer-based materials (i.e. plastics) produced yearly are a great challenge for humanity. Nature produces even more natural polymers, yet they are sustainable. Proteins are sequence-defined natural polymers that are constantly recycled… read more here.
Keywords: recycling proteins; amino acids; nature inspired; circular economy ... See more keywords
Tuning the Magnetization of Manganese (II) Carbonate by Intracrystalline Amino Acids
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202201652
Abstract: Incorporation of organic molecules into the lattice of inorganic crystalline hosts is a common phenomenon in biomineralization and is shown to alter various properties of the crystalline host. Taking this phenomenon as a source of… read more here.
Keywords: amino acids; magnetization manganese; manganese carbonate; tuning magnetization ... See more keywords
Green and one‐pot surface coating of iron oxide magnetic nanoparticles with natural amino acids and biocompatibility investigation
Sign Up to like & getrecommendations! Published in 2018 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.4069
Abstract: We report the synthesis of iron oxide magnetic nanoparticles (IONPs) coated with various natural amino acids (AAs) using a one-pot reaction in an aqueous medium. Several AAs, which contained hydrophilic and hydrophobic groups, were selected… read more here.
Keywords: natural amino; amino acids; iron oxide; magnetic nanoparticles ... See more keywords
An efficient cell‐free protein synthesis platform for producing proteins with pyrrolysine‐based noncanonical amino acids
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202200096
Abstract: Incorporation of noncanonical amino acids (ncAAs) into proteins opens new opportunities in biotechnology and synthetic biology. Pyrrolysine (Pyl)‐based ncAAs are some of the most predominantly used, but expression systems suffer from low yields. Here, we… read more here.
Keywords: amino acids; platform; synthesis; noncanonical amino ... See more keywords
N‐methylation in amino acids and peptides: Scope and limitations
Sign Up to like & getrecommendations! Published in 2018 at "Biopolymers"
DOI: 10.1002/bip.23110
Abstract: Active pharmaceutical ingredients (APIs) can be divided into two types, namely chemical and biological entities. Traditionally, the former has been associated with the so‐called small molecules. The revival of peptides in pharmaceutical industry results from… read more here.
Keywords: peptide; amino acids; methylation amino; acids peptides ... See more keywords
Flexible customization of the self‐assembling abilities of short elastin‐like peptide Fn analogs by substituting N‐terminal amino acids
Sign Up to like & getrecommendations! Published in 2022 at "Biopolymers"
DOI: 10.1002/bip.23521
Abstract: Elastin‐like peptides (ELPs) are thermoresponsive biopolymers inspired by the characteristic repetitive sequences of natural elastin. As ELPs exhibit temperature‐dependent reversible self‐assembly, they are expected to be biocompatible thermoresponsive materials for drug delivery carriers. One of… read more here.
Keywords: self assembling; amino acids; amino; elastin like ... See more keywords
In vitro suppression of two different stop codons
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26226
Abstract: Proteins play a crucial role in all living organisms, with the 20 natural amino acids as their building blocks. Unnatural amino acids are synthetic derivatives of these natural building blocks. These amino acids have unique… read more here.
Keywords: amino acids; different stop; two different; unnatural amino ... See more keywords
Engineering active lysostaphin variants that incorporate noncanonical amino acids and characterizing the effects of site‐specific PEGylation
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28360
Abstract: We describe a facile strategy to identify sites for the incorporation of noncanonical amino acids into lysostaphin—an enzyme that degrades the cell wall of Staphylococcus aureus—while retaining stapholytic activity. We used this strategy to generate… read more here.
Keywords: amino acids; lysostaphin variants; site specific; site ... See more keywords
Sustainable and Continuous Synthesis of Enantiopure l‐Amino Acids by Using a Versatile Immobilised Multienzyme System
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201700493
Abstract: The enzymatic synthesis of α‐amino acids is a sustainable and efficient alternative to chemical processes, through which achieving enantiopure products is difficult. To more address this synthesis efficiently, a hierarchical architecture that irreversibly co‐immobilises an… read more here.
Keywords: system; amino acids; enantiopure; synthesis ... See more keywords