Ionizable Amino-Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino-Alcohols for Tissue Selective mRNA Delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced materials"
DOI: 10.1002/adma.201801151
Abstract: The utility of messenger RNA (mRNA) as a therapy is gaining a broad interest due to its potential for addressing a wide range of diseases, while effective delivery of mRNA molecules to various tissues still… read more here.
Keywords: amino; delivery; amino polyesters; amino alcohols ... See more keywords
Efficient preparation of stereopure amphiphilic 1,2-amino alcohols by using preparative enantioselective HPLC.
Sign Up to like & getrecommendations! Published in 2021 at "Chirality"
DOI: 10.1002/chir.23395
Abstract: Chiral amphiphiles are useful for controlling the structures and properties of supramolecular assemblies, but their stereocontrolled synthesis is generally difficult, because their long alkyl chains tend to bring unfavorable effects on the solubility, reactivity, and… read more here.
Keywords: amphiphilic amino; amino alcohols; overall yield; hplc ... See more keywords
SYNTHESIS OF FUNCTIONALIZED OXAZOLIDINES BY MULTICOMPONENT REACTIONS OF 1,2-AMINO ALCOHOLS
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/5439
Abstract: Recent (2011–2019) multicomponent syntheses of functionalized oxazolidines using 1,2-amino alcohols as starting materials are reviewed. The synthetic strategies are gathered into three groups: metal-free domino annulation/Mannich reactions, transition metal-catalyzed cascade reactions, extended one-pot asymmetric azaelectrocyclization. read more here.
Keywords: multicomponent reactions; functionalized oxazolidines; synthesis functionalized; reactions amino ... See more keywords
Generation and hydrolysis of N-acyloxazolinium salts allowing regiospecific acylation of chiral amino alcohols
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-020-02707-3
Abstract: In an attempt to form 2-alkylidene-1,3-oxazolidines, chiral 2-oxazolines have been N-alkylated and N-acylated. Two new N-methyloxazolinium salts have been prepared and characterized, but alkaline treatment resulted in their decomposition. In contrast, attempts to isolate three… read more here.
Keywords: amino; acyloxazolinium salts; generation hydrolysis; hydrolysis acyloxazolinium ... See more keywords
Carane amino alcohols as organocatalysts in asymmetric aldol reaction of isatin with acetone
Sign Up to like & getrecommendations! Published in 2017 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-017-1730-y
Abstract: Carane-derived β-amino alcohols with amino and hydroxy groups at positions 3 and 4 differing in their mutual arrangement and configuration were synthesized. Their application as organocatalysts in the asymmetric aldol reaction of isatin with acetone… read more here.
Keywords: isatin acetone; aldol reaction; organocatalysts asymmetric; amino alcohols ... See more keywords
Synthesis of optically active 3,3’-disubstituted biphenyl derivatives using palladium-catalyzed amination and their evaluation as enantioselective fluorescent detectors for amino alcohols and metal cations
Sign Up to like & getrecommendations! Published in 2020 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-020-2911-7
Abstract: The palladium-catalyzed amination was used to synthesize optically active 3,3’-diaminosubstituted biphenyl derivatives (in particular, macrocyclic derivatives) decorated with additional fluorophore groups (dansyl and 7-methoxycoumarin). The synthesized compounds were studied by spectroscopic methods (UV spectroscopy, fluorescence)… read more here.
Keywords: optically active; biphenyl derivatives; palladium catalyzed; amino alcohols ... See more keywords
Rationally designed benzopyran fused isoxazolidines and derived β2,3,3-amino alcohols as potent analgesics: Synthesis, biological evaluation and molecular docking analysis.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.12.052
Abstract: Based on structure activity analysis of morphine related opiates, we have synthesized some novel benzopyran fused isoxazolidines (2a-e) and derived conformationally constrained β2,3,3-amino alcohols (3a-e), which were evaluated in vivo for their anti-nociceptive activity through acetic… read more here.
Keywords: analysis; benzopyran fused; isoxazolidines derived; amino alcohols ... See more keywords
β-amino alcohols and their respective 2-phenyl-N-alkyl aziridines as potential DNA minor groove binders.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.07.055
Abstract: It is known that aziridines and nitrogen mustards exert their biological activities, especially in chemotherapy, via DNA alkylation. The studied scaffold, 2-phenyl-1-aziridine, provides a distinct conformation compared to commonly used aziridines, and therefore, leads to… read more here.
Keywords: dna; alcohols respective; minor groove; amino alcohols ... See more keywords
Chiral sensor for enantiomeric purity of amines, amino alcohols and amino esters based on bis-cyclometalated Ir(III) complex using 1H NMR spectroscopy
Sign Up to like & getrecommendations! Published in 2018 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2018.07.010
Abstract: Abstract A new chiral sensor assembly with enantiomeric Ir(III) complex Δ-[Ir(ppy)2(MeCN)2](PF6) (ppy is 2-phenylpyridine) and 3-hydroxypyridine-2-carboxaldehyde as anxiliaries for chiral amines and amino derivatives, including α-amines, α-amino alcohols, α-amino esters, β-amines and β-amino alcohols as… read more here.
Keywords: iii; amino; amines amino; nmr spectroscopy ... See more keywords
β-Amino alcohols from anilines and ethylene glycol through heterogeneous Borrowing Hydrogen reaction
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.08.006
Abstract: Abstract Borrowing Hydrogen (BH), also called Hydrogen Autotransfer (HA), reaction with neat ethylene glycol represents a key step in the preparation of β-amino alcohols. However, due to the stability of ethylene glycol, mono-activation has rarely… read more here.
Keywords: reaction; amino alcohols; ethylene glycol; borrowing hydrogen ... See more keywords
Nickel-Catalyzed Direct Synthesis of N-Substituted Indoles from Amino Alcohols and Alcohols.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03617
Abstract: A one-pot cascade approach for the synthesis of N-substituted indoles from amino alcohols and alcohols under additive and base-free conditions with the liberation of water as the only stoichiometric byproduct is reported. The commercially available… read more here.
Keywords: synthesis substituted; indoles amino; alcohols alcohols; substituted indoles ... See more keywords