Palladium-Catalyzed β-C-H Arylation of Aliphatic Aldehydes and Ketones Using Amino Amide as a Transient Directing Group.
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DOI: 10.1021/acs.orglett.9b00366
Abstract: This paper describes a new amino-amide-based transient directing group (TDG). The TDG can exhibit better performance in the Pd-catalyzed arylation of aliphatic aldehydes and ketones. This reaction showed good substrate compatibility and regioselectivity. The results… read more here.
Keywords: aliphatic aldehydes; directing group; arylation aliphatic; amino amide ... See more keywords