Novel Approach to the Synthesis of 3-amino-4-arylpyridin-2(1H)-one Derivatives
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DOI: 10.1007/s10593-021-02980-w
Abstract: The reaction of 4-arylidene-2-phenyloxazol-5(4H)-ones with enamines of ethyl acetoacetate gave 4-aryl-2-methyl-6-oxo-5-[(phenylcarbonyl)amino]-1,4,5,6-tetrahydropyridine-3-carboxylic acid esters, which, when heated with phosphorus oxychloride, were converted into esters of 7-aryl-5-methyl-2-phenyloxazolo[5,4-b]pyridine-6-carboxylic acids. Alkaline hydrolysis of these compounds gave 4-aryl-2-methyl-6-oxo-5-[(phenylcarbonyl)amino]-1,6-dihydropyridine-3-carboxylic acid esters. read more here.
Keywords: aryl methyl; amino; novel approach; synthesis amino ... See more keywords
Synthesis and Photophysical Properties of 3-Amino-4-arylpyridin-2(1Н)-ones
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DOI: 10.1055/s-0039-1690231
Abstract: A method has been developed for the preparation of oxazolo-[5,4-b]pyridin-2(1H)-ones based on the Hoffmann reaction of 2-oxo-1,2-dihydropyridine-3-carboxamides. Hydrolysis of oxazolo[5,4-b]pyridin-2(1H)-ones and the Hoffmann reaction of 2-oxo-1,2-dihydropyridine-3-carboxamides yielded 3-aminopyridin-2(1H)-ones, including 4-aryl substituted derivatives in the series,… read more here.
Keywords: photophysical properties; synthesis photophysical; amino arylpyridin; spectroscopy ... See more keywords