α-Functionalized ketene N,S-acetals as two-carbon synthons in the reaction with 1,2-naphthoquinone 1-methide. Synthesis of 3-amino-1H-benzo[f]chromenes
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DOI: 10.1007/s10593-020-02694-5
Abstract: A series of 3-amino-1H-benzo[f]chromenes were obtained in the reaction of 1-[(dimethylamino)methyl]naphthalen-2-ol with push-pull ketene N,S-acetals containing an electron-withdrawing group in the α-position. It is assumed that the reaction proceeds as a [4+2] cycloaddition of ketene… read more here.
Keywords: amino benzo; functionalized ketene; benzo chromenes; ketene acetals ... See more keywords
Application of nitrogen-rich porous organic polymer for the solid-phase synthesis of 2-amino-4H-benzo[b]pyran scaffolds using ball milling process
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DOI: 10.1007/s11030-020-10092-4
Abstract: Abstract This paper presents the efficient synthesis of 2-amino-4 H -benzo[ b ]pyrans using mesoporous poly-melamine-formaldehyde as a polymeric heterogeneous catalyst. According to the principals of green chemistry, the reaction was performed by the planetary… read more here.
Keywords: ball milling; amino benzo; synthesis amino; milling process ... See more keywords
Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.
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DOI: 10.1016/j.ejmech.2020.112108
Abstract: Aurora A kinase, a member of the Aurora kinase family, is frequently overexpressed in various human cancers. In addition, Overexpression of Aurora A kinase is associated with drug resistance and poor prognosis in many cancers… read more here.
Keywords: amino benzo; kinase; imidazole quinazolin; benzo imidazole ... See more keywords
Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00994
Abstract: This work describes the discovery and characterization of novel 6-(1 H-pyrazolo[4,3- b]pyridin-3-yl)amino-benzo[ d]isothiazole-3-carboxamides as mGlu4 PAMs. This scaffold provides improved metabolic clearance and CYP1A2 profiles compared to previously discovered mGlu4 PAMs. From this work, 27o… read more here.
Keywords: characterization novel; amino benzo; pyrazolo pyridin; benzo isothiazole ... See more keywords
Oxidant-free, three-component synthesis of 7-amino-6H-benzo[c]chromen-6-ones under green conditions
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DOI: 10.1039/c9ra07108c
Abstract: Three-component synthesis of 7-amino-6H-benzo[c]chromen-6-ones was achieved under oxidant-free green conditions. read more here.
Keywords: amino benzo; benzo chromen; component synthesis; synthesis amino ... See more keywords