Development of a method for the quantitative metabolite profiling of pharmaceutical drugs using HPLC-ICP-MS following pre-column derivatization of their amino and hydroxyl groups using 4-aminopyridine as a model compound
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DOI: 10.1039/c8ja00386f
Abstract: Presence of amino and/or hydroxyl groups allows for derivatization of APIs and their metabolites with 4-iodobenzoylchloride, thus enabling HPLC-ICP-MS metabolite profiling. read more here.
Keywords: metabolite profiling; amino hydroxyl; hydroxyl groups; hplc icp ... See more keywords