Copper-catalyzed tandem radical amination/1,2-carbon migration of allylic alcohols: Direct access to α-quaternary-β-amino ketones
Sign Up to like & getrecommendations! Published in 2018 at "Chinese Journal of Catalysis"
DOI: 10.1016/s1872-2067(18)63028-1
Abstract: Abstract A novel nitrogen-centered radical-induced 1,2-carbon migration reaction of allylic alcohols has been developed. This method provides easy access to a variety of α-quaternary-β-amino ketones under mild reaction conditions. The reaction has a wide substrate… read more here.
Keywords: amino ketones; quaternary amino; carbon; allylic alcohols ... See more keywords
Chiral Primary Amine Catalyzed Enantioselective Tandem Reactions Based on Heyns Rearrangement: Synthesis of α-Tertiary Amino Ketones.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00724
Abstract: Herein, we disclose a new catalytic asymmetric tandem reaction based on the Heyns rearrangement for the synthesis of chiral α-amino ketones with readily available substrates. The rearrangement is different from the Heyns rearrangement in that… read more here.
Keywords: based heyns; heyns rearrangement; amino ketones; chiral primary ... See more keywords
Nickel-Catalyzed Formation of α-Substituted γ-Amino Ketones via Alkene Carboacylation.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03413
Abstract: Herein, we report Ni-catalyzed intramolecular carboacylation of imides containing a tethered alkene and tetraarylborate nucleophiles. Using a nickel-phosphine catalyst system, α-substituted, γ-amino ketones are generated in up to 92% yield with site selectivity. Deprotection and… read more here.
Keywords: catalyzed formation; nickel catalyzed; amino ketones; substituted amino ... See more keywords
Stereospecific Overman Rearrangement of Substituted Cyclic Vinyl Bromides: Access to Fully Substituted α-Amino Ketones.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03347
Abstract: A versatile thermal Overman rearrangement of enantioenriched, cyclic allylic alcohols providing tertiary allylic amines has been developed. The vinyl bromide used to control enantioselectivity in a preceding CBS reduction is utilized as a synthetic handle… read more here.
Keywords: amino ketones; rearrangement substituted; stereospecific overman; overman rearrangement ... See more keywords
Direct Enantioselective C(sp3)-H Acylation for the Synthesis of α-Amino Ketones.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c10471
Abstract: A direct enantioselective acylation of α-amino C(sp3)-H bonds with carboxylic acids has been achieved via the merger of transition metal and photoredox catalysis. This straightforward protocol enables cross-coupling of a wide range of carboxylic acids,… read more here.
Keywords: amino ketones; amino; sp3; acylation ... See more keywords
Enantioselective Oxidative Multi-Functionalization of Terminal Alkynes with Nitrones and Alcohols for Expeditious Assembly of Chiral α-Alkoxy-β-amino-ketones.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c06178
Abstract: Catalytic oxidative functionalization of alkynes has emerged as an effective method in synthetic chemistry in recent decades. However, enantioselective transformations via metal carbene intermediates are quite rare due to the lack of robust chiral catalysts,… read more here.
Keywords: amino ketones; alkynes nitrones; alkoxy amino; multi functionalization ... See more keywords
On the Origin of Rh-Catalyzed Selective Ring-Opening Amidation of Substituted Cyclopropanols to Access β2-Amino Ketones.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12934
Abstract: β2-Amino carbonyls, an α-substituted β-amino scaffold, hold a prominent place in the development of new pharmaceuticals and peptidomimetics. Herein, we report a highly efficient Rh-catalyzed ring-opening amidation of substituted cyclopropanols, which turned out to serve… read more here.
Keywords: amidation substituted; substituted cyclopropanols; amino ketones; amino ... See more keywords
Efficient access to chiral 1,2-amino alcohols via Ir/f-amphox-catalyzed asymmetric hydrogenation of α-amino ketones
Sign Up to like & getrecommendations! Published in 2017 at "Organic chemistry frontiers"
DOI: 10.1039/c7qo00237h
Abstract: Tridentate f-amphox ligands were successfully applied to the iridium-catalyzed asymmetric hydrogenation of various α-amino ketones to afford a series of chiral 1,2-amino alcohols with excellent results (all products up to >99% conversion and >99% ee,… read more here.
Keywords: amino ketones; catalyzed asymmetric; amino; asymmetric hydrogenation ... See more keywords
Visible-light promoted sulfonamidation of enol acetates to α-amino ketones based on redox-neutral photocatalysis
Sign Up to like & getrecommendations! Published in 2019 at "Organic Chemistry Frontiers"
DOI: 10.1039/c9qo01119f
Abstract: A visible-light mediated photoredox-catalyzed sulfonamidation of enol acetates to α-amino ketones has been developed. The process features mild and operationally simple reaction conditions and does not require an external oxidant. read more here.
Keywords: amino ketones; enol acetates; acetates amino; visible light ... See more keywords
Palladium-catalyzed oxidative cross-coupling for the synthesis of α-amino ketones
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DOI: 10.1039/c9ra06108h
Abstract: A novel oxidative cross-coupling reaction for the synthesis of α-aryl α-amino ketones in the presence of palladium catalysts using T+BF4− as an oxidant has been developed. read more here.
Keywords: oxidative cross; synthesis; cross coupling; amino ketones ... See more keywords
In vitro and in silico assessment of new beta amino ketones with antiplasmodial activity
Sign Up to like & getrecommendations! Published in 2022 at "Revista da Sociedade Brasileira de Medicina Tropical"
DOI: 10.1590/0037-8682-0590-2022
Abstract: ABSTRACT Background: Based on the current need for new drugs against malaria, our study evaluated eight beta amino ketones in silico and in vitro for potential antimalarial activity. Methods: Using the Brazilian Malaria Molecular Targets… read more here.
Keywords: antiplasmodial activity; amino ketones; beta amino;